Sustained Release of a Water-Soluble Drug from Alginate Matrix Tablets Prepared by Wet Granulation Method

详细信息    查看全文

• 作者：Sanchita Mandal (1)
  Sanat Kumar Basu (1)
  Biswanath Sa (1)
  
• 关键词：calcium gluconate ; diltiazem hydrochloride ; matrix tablet ; pH modulator ; sodium alginate
• 刊名：AAPS PharmSciTech
• 出版年：2009
• 出版时间：December 2009
• 年：2009
• 卷：10
• 期：4
• 页码：1348-1356
• 全文大小：309KB
• 参考文献：1. Vayas SP, Khar RP. Controlled drug delivery concepts and advances. Delhi: Vallabh Prakashan; 2002. p. 102.
  2. Tapia C, Costa E, Moris M, Sapag-Hagar J, Valenzuela F, Basualto C. Study of the influence of the pH media dissolution, degree of polymerization, and degree of swelling of the polymers on the mechanism of release of diltiazem from matrices based on mixtures of chitosan/alginate. Drug Dev Ind Pharm. 2002;28(2):217-4. CrossRef
  3. Sriamornsak P, Thirawong N, Korkerd K. Swelling, erosion and release behavior of alginate-based matrix tablets. Eur J Pharm Biopharm. 2007;66:435-0. CrossRef
  4. Aslani P, Kennedy RA. Studies on diffusion in alginate gels, I. Effects of cross-linking with calcium or zinc ions on diffusion of acetaminophen. J Control Release. 1996;42:75-2. CrossRef
  5. Liew CV, Chan LW, Ching AL, Heng PWS. Evaluation of sodium alginate as drug release modifier in matrix tablets. Int J Pharm. 2006;309:25-7. CrossRef
  6. Polk A, Amsden B, Yao KD, Peng T, Goosen MFA. Controlled release of albumin from chitosan-alginate microcapsules. J Pharm Sci. 1994;83:178-5. CrossRef
  7. Kikuchi A, Kawabuchi M, Sugihara M, Sakurai Y, Okano T. Controlled release of macromolecular dextran from calcium-alginate gel beads. Proc Int Symp Control Rel Bioact Mater. 1996;23:737-.
  8. Bowersock TL, HogenEsch H, Suckow M, Guimond P, Martin S, Borie D, / et al. Oral vaccination of animals with antigens encapsulated in alginate microspheres. Vaccine. 1999;17:1804-1. CrossRef
  9. Cui JH, Goh JS, Park SY, Kim PH, Le BJ. Preparation and physical characterization of alginate microparticles using air atomization method. Drug Dev Ind Pharm. 2001;27:309-9. CrossRef
  10. Gonzalez-Rodriguez ML, Holgado MA, Sanchez-Lafuente C, Rabasco AM, Fini A. Alginate/chitosan particulate systems for sodium diclofenac release. Int J Pharm. 2002;232:225-4. CrossRef
  11. Halder A, Maiti S, Sa B. Entrapment efficiency and release characteristics of polyethyleneimine-treated or -untreated calcium alginate beads loaded with propranolol-resign complex. Int J Pharm. 2005;302:84-4. CrossRef
  12. Giunchedi P, Gavini E, Moretti MDl, Pirisino G. Evaluation of alginate compressed matrixes as prolonged drug delivery systems. AAPS PharmSciTech. 2000;1(3):31-. CrossRef
  13. Bayomi MA, Al-Suwayeh SA, El-Heiw AM. Excipient–excipient interaction in the design of sustained-release theophylline tablets: / in vitro and / in vivo evaluation. Drug Dev Ind Pharm. 2001;27(6):499-06. CrossRef
  14. Nokhodchi A, Tailor A. / In situ cross-linking of sodium alginate with calcium and aluminum ions to sustained the release of theophylline from polymeric matrices. Il Farmaco. 2004;59:999-004. CrossRef
  15. Barnhart ER. Physicians' desk reference. 45th ed. Oradell: Medical Economics; 1991. p. 1293.
  16. Goodman LS, Gilman A. The pharmacological basis of therapeutics. 7th ed. New York: Macmillan; 1985.
  17. Chaffman M, Brogden RN. Diltiazem, a review of its pharmacological properties and therapeutics efficacy. Drugs. 1985;29:387-54. CrossRef
  18. Maxxo DJ, Obetz CI, Shuster J. Diltiazem hydrochloride. In: Brittain H, editor. Analytical profiles of drug substances and excipients, vol. 23. New York: Academic; 1994. p. 53-8.
  19. Yotsuyanagi T, Ohkubo T, Ohhashi T, Ikeda K. Calcium induced gelation of alginic acid and pH-sensitive reswelling of dried gels. Chem Pharm Bull. 1987;35:1555-3.
  20. Tomida H, Mizuo C, Nakamura C, Kiryu S. Imipramine release from Ca-alginate gel beads. Chem Pharm Bull. 1993;41:1475-.
  21. Kikuchi A, Kawabuchi M, Sugihara M, Sakurai Y, Okano T. Pulsed dextran release from calcium-alginate gel beads. J Control Release. 1997;47:21-. CrossRef
  22. Timmins P, Delargy AM, Minchom CM, Howard R. Influence of some process variables on product properties for a hydrophilic matrix controlled release tablet. Eur J Pharm Biopharm. 1992;38:113-.
  23. Bettini R, Colombo P, Massimo G, Catellani PL, Vitali T. Swelling and drug release in hydrogel matrices: polymer viscosity and matrix porosity effects. Eur J Pharm Sci. 1994;2:213-. CrossRef
  24. Velasco MV, Ford JL, Rowe P, Rajabi-Siahboomi AR. Influence of drug:hydroxypropylmethylcellulose ratio, drug and polymer particle size and compression force on the release of diclofenac sodium from hydroxypropylmethylcellulose tablets. J Control Release. 1999;57:75-5. CrossRef
  25. Ching AL, Liew CV, Chan LW, Heng PWS. Modifying matrix micro-environmental pH to achieve sustained drug release from highly laminating alginate matrices. Eur J Pharm Sci. 2008;33:361-0. CrossRef
  26. Streubel A, Siepmann J, Dashevsky A, Bodmeier R. pH-independent release of a weakly basic drug from water-insoluble and -soluble matrix tablets. J Control Release. 2000;67:101-0. CrossRef
  27. Tatavarti AS, Hoag SW. Micro-environmental pH modulation based release enhancement of a weakly basic drug from hydrophilic matrices. J Pharm Sci. 2006;95(7):1459-8. CrossRef
  
• 作者单位：Sanchita Mandal (1)
  Sanat Kumar Basu (1)
  Biswanath Sa (1)
  
  1. Division of Pharmaceutics, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, 700032, India
  

文摘

Alginate matrix tablet of diltiazem hydrochloride (DTZ), a water-soluble drug, was prepared using sodium alginate (SAL) and calcium gluconate (CG) by the conventional wet granulation method for sustained release of the drug. The effect of formulation variables like SAL/CG ratio, drug load, microenvironmental pH modulator, and processing variable like compression force on the extent of drug release was examined. The tablets prepared with 1:2 w/w ratio of SAL/CG produced the most sustained release of the drug extending up to 13.5?h. Above and below this ratio, the drug release was faster. The drug load and the hardness of the tablets produced minimal variation in drug release. The addition of alkaline or acidic microenvironmental modulators did not extend the release; instead, these excipients produced somewhat faster release of diltiazem. This study revealed that proper selection of SAL/CG ratio is important to produce alginate matrix tablet by wet granulation method for sustained release of DTZ.