Potentiation of the NO-cGMP pathway and blood flow responses during dynamic exercise in healthy humans
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- 作者：Jacqueline K. Limberg ; Katherine R. Malterer…
- 关键词：Blood flow ; Regional ; Sildenafil ; Exercise ; Nitric oxide ; Cyclic GMP
- 刊名：European Journal of Applied Physiology
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：117
- 期：2
- 页码：237-246
- 全文大小：
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Human Physiology; Occupational Medicine/Industrial Medicine; Sports Medicine;
- 出版者：Springer Berlin Heidelberg
- ISSN：1439-6327
- 卷排序：117
文摘
PurposePrevious work has shown nitric oxide (NO) contributes to ~15% of the hyperemic response to dynamic exercise in healthy humans. This NO-mediated vasodilation occurs, in part, via increases in intracellular cyclic guanosine monophosphate (cGMP), which is catabolized by phosphodiesterase. We sought to examine the effect of phosphodiesterase-5 (PDE-5) inhibition on forearm blood flow (FBF) responses to dynamic handgrip exercise in healthy humans and the role of NO. We hypothesized exercise hyperemia would be augmented by sildenafil citrate (SDF, PDE-5 inhibitor). We further hypothesized any effect of SDF on exercise hyperemia would be abolished with intra-arterial infusion of the NO synthase (NOS) inhibitor L-NG-monomethyl arginine (L-NMMA).