Endoluminal and Interstitial Brachytherapy for the Treatment of Gastrointestinal Malignancies: a Systematic Review

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• 作者：Sujana Gottumukkala ; Vasu Tumati ; Brian Hrycushko…
• 关键词：Brachytherapy ; Endoluminal brachytherapy ; Interstitial brachytherapy ; High ; dose rate brachytherapy ; Low ; dose rate brachytherapy ; Gastrointestinal malignancy ; Palliative care ; Biliary brachytherapy ; Endoesophageal brachytherapy ; Endorectal brachytherapy
• 刊名：Current Oncology Reports
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：19
• 期：1
• 全文大小：
• 刊物主题：Oncology;
• 出版者：Springer US
• ISSN：1534-6269
• 卷排序：19

文摘

Radiation therapy is an integral component in the multimodality management of many gastrointestinal (GI) cancers at all stages of clinical presentation. With recent advances in technology and radiation delivery, external beam radiation therapy (EBRT) can be delivered with reduced toxicity. However, despite these advances, EBRT doses are still limited by the presence of radiosensitive serial structures near clinical targets in the GI tract. Relative to EBRT techniques, brachytherapy techniques have a lower integral dose and more rapid fall-off, allowing for high-dose delivery with little normal tissue exposure. Given the unique characteristics of brachytherapy, it is an attractive strategy to treat GI malignancies. This review addresses the application of both high-dose rate brachytherapy (HDRBT) and low-dose rate brachytherapy (LDRBT) to multiple GI malignancies for both definitive and palliative management.