Association of chromosome 19 to lung cancer genotypes and phenotypes

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• 作者：Xiangdong Wang ; Yong Zhang ; Carol L. Nilsson…
• 关键词：Proteins ; Genes ; Antibodies ; mRNA ; Mass spectrometry ; Bioinformatics ; Protein microarray ; Human disease
• 刊名：Cancer and Metastasis Reviews
• 出版年：2015
• 出版时间：June 2015
• 年：2015
• 卷：34
• 期：2
• 页码：217-226
• 全文大小：1,096 KB
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• 作者单位：Xiangdong Wang (1)
  Yong Zhang (1)
  Carol L. Nilsson (15) (2)
  Frode S. Berven (3)
  Per E. Andrén (4)
  Elisabet Carlsohn (5)
  Peter Horvatovich (6)
  Johan Malm (7)
  Manuel Fuentes (8)
  ákos Végvári (9)
  Charlotte Welinder (10)
  Thomas E. Fehniger (16) (9)
  Melinda Rezeli (11)
  Goutham Edula (12)
  Sophia Hober (13)
  Toshihide Nishimura (14)
  Gy?rgy Marko-Varga (14) (9)
  
  1. Zhongshan Hospital, Shanghai Institute of Clinical Bioinformatics, Fudan University, Shanghai, China
  15. Department of Clinical Sciences, CEBMMS, Lund University, 22100, Lund, Sweden
  2. Department of Pharmacology and Toxicology, UTMB Cancer Center, University of Texas Medical Branch, Galveston, TX, 77555, USA
  3. Department of Biomedicine, University of Bergen, 5009, Bergen, Norway
  4. Department of Pharmaceutical Biosciences, Biomolecular Imaging and Proteomics, Uppsala University, 751 24, Uppsala, Sweden
  5. Proteomics Core Facility, G?teborg University, 413 90, G?teborg, Sweden
  6. Department of Pharmacy, Analytical Biochemistry, University of Groningen, A. Deusinglaan 1, 9713 AV, Groningen, The Netherlands
  7. Department of Translational Medicine, Section for Clinical Chemistry, Lund University, Sk?ne University Hospital Malm?, SE-205 02, Malm?, Sweden
  8. Centro de Investigación del Cáncer/IBMCC (USAL/CSIC)-IBSAL, Unidad de Proteomica, Departamento de Medicina and Servicio General de Citometría-Nucleus, University of Salamanca, 37007, Salamanca, Spain
  9. Department of Biomedical Engineering, Clinical Protein Science and Imaging, Biomedical Center, Lund University, BMC D13, 221 00, Lund, Sweden
  10. Department of Oncology and Pathology, Clinical Sciences, Lund University, 221 85, Lund, Sweden
  16. Center of Excellence in Biological and Medical Mass Spectrometry, CEBMMS, Lund University, BMC D13, 221 00, Lund, Sweden
  11. Department of Biomedical Engineering, Clinical Protein Science & Imaging, Lund University, BMC D13, 221 84, Lund, Sweden
  12. Clinnovo Research Labs, Hyderabad, India
  13. Department of Proteomics, School of Biotechnology, Royal Institute of Technology, 106 91, Stockholm, Sweden
  14. First Department of Surgery, Tokyo Medical University, 6-7-1 Nishishinjiku Shinjiku-ku, Tokyo, 160-0023, Japan
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  Cancer Research
  
• 出版者：Springer Netherlands
• ISSN：1573-7233

文摘

The Chromosome 19 Consortium, a part of the Chromosome-Centric Human Proteome Project (C-HPP, http://?www.?C-HPP.?org), is tasked with the understanding chromosome 19 functions at the gene and protein levels, as well as their roles in lung oncogenesis. Comparative genomic hybridization (CGH) studies revealed chromosome aberration in lung cancer subtypes, including ADC, SCC, LCC, and SCLC. The most common abnormality is 19p loss and 19q gain. Sixty-four aberrant genes identified in previous genomic studies and their encoded protein functions were further validated in the neXtProt database (http://?www.?nextprot.?org/-/span>). Among those, the loss of tumor suppressor genes STK11, MUM1, KISS1R (19p13.3), and BRG1 (19p13.13) is associated with lung oncogenesis or remote metastasis. Gene aberrations include translocation t(15, 19) (q13, p13.1) fusion oncogene BRD4-NUT, DNA repair genes (ERCC1, ERCC2, XRCC1), TGFβ1 pathway activation genes (TGFB1, LTBP4), Dyrk1B, and potential oncogenesis protector genes such as NFkB pathway inhibition genes (NFKBIB, PPP1R13L) and EGLN2. In conclusion, neXtProt is an effective resource for the validation of gene aberrations identified in genomic studies. It promises to enhance our understanding of lung cancer oncogenesis.