Exposure of nursery school children and their parents and teachers to di-n-butylphthalate and butylbenzylphthalate

详细信息    查看全文

• 作者：Holger M. Koch ; Ralf Preuss ; Hans Drexler and Jürgen Angerer
• 关键词：Children ; Phthalates ; Urine ; Biological monitoring ; Di ; n ; butylphthalate ; Mono ; n ; butylphthalate ; Butylbenzylphthalate ; Mono ; benzylphthalate
• 刊名：International Archives of Occupational and Environmental Health
• 出版年：2005
• 出版时间：April 2005
• 年：2005
• 卷：78
• 期：3
• 页码：223-229
• 全文大小：292 KB
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Occupational and Industrial Medicine
  Environmental Medicine/Environmental Psychology
  Rehabilitation
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1432-1246

文摘

Objectives: Some phthalates, among them di-n-butylphthalate (DnBP) and butylbenzylphthalate (BBzP), are known reproductive and developmental toxicants in animals and suspected endocrine disruptors in humans. Children are probably the most susceptible to these effects. To obtain an estimate of internal exposure to DnBP and BBzP we compared the excretion of their metabolites in the urine of nursery school children with that of their teachers and parents. Methods: We measured the urinary mono-ester metabolites of DnBP, mono-n-butylphthalate (MnBP), and BBzP, monobenzylphthalate (MBzP), in first-morning voids of 36 children (median age 4.7 years) and 19 adults (37.4 years). Results: In all samples both metabolites were detected. Urinary MnBP concentrations (in microgrammes per litre) of the children and adults were 139 and 91.8 (median), respectively. MBzP concentrations were 22.1 g/l and 12.7 g/l (median), respectively. Concentrations in microgrammes per gramme creatinine for MnBP were 161 for the children and 91.8 for the adults (median). The maximum concentration found for children (2249 g/g) was approximately 15-times higher than that for adults (149 g/g). This maximum value for children was attributed to medication that contained DnBP. If this child was excluded, the maximum concentration was 517 g/g. MBzP concentrations for children and adults were 37.0 g/g and 9.8 g/g (median), respectively. The maximum concentration found for children (193 g/g) was approximately seven-times higher than that for adults (26.7 g/g). Creatinine-adjusted concentrations were significantly higher for children for both MBzP and MnBP (Ps cohort (r=0.723, Ps cohort we found elevated MnBP exposure to be caused by augmented use of skin-care products (PConclusion: We have shown that the internal exposure to MnBP and MBzP in children is approximately two- to four-times higher than in adults. Correlation of internal MnBP with MBzP exposure points to common sources of exposure for both phthalates. DnBP exposure seems, at least in part, to be connected with the use of body/skin care products and certain medications.