Prognostic relevance of cathepsin D detection in micrometastaticcells in the bone marrow of patients with primary breast cancer

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• 作者：Solomayer ; E F. ; Diel ; I.J. ; Meyberg ; G.C. ; Gollan ; Ch. ; Bode ; S. ; Wallwiener ; D. ; Bastert ; G.
• 关键词：tumour cell detection ; cathepsin D ; breast cancer ; micrometastasis ; prognostic factor
• 刊名：Breast Cancer Research and Treatment
• 出版年：1998
• 出版时间：1998
• 年：1998
• 卷：49
• 期：2
• 页码：145-154
• 全文大小：1.14 MB

文摘

Patients with an elevated level of cathepsin D in breast cancer tissuehave an adverse prognosis. This study evaluated the prognostic relevance ofcathepsin D detection in disseminated tumour cells in bone marrow. Bonemarrow was sampled intraoperatively from both anterior iliac crests in 290patients with primary breast cancer. Interphase cells were enhanced andstained immunocytologically with two antibodies: BM2, which detectstumour-associated glycoprotein TAG 12, which is typically expressed byalmost all breast cancer cells, and the anti-cathepsin D antibody. 67 of 149BM2-positive women (45%) developed metastatic disease (medianfollow-up time: 69 months). Of these, 15 were cathepsin D-positive(22%). Patients with cathepsin D-positive cells in bone marrow (n= 26; 9%) had a significantly shorter metastasis-free interval(38 months) compared with women who were cathepsin D-negative (64.5 months).The worst prognosis was seen in patients positive for both markers (30.5months), followed by those who were cathepsin D-negative and BM2-positive(48 months). The detection of cathepsin D on disseminated tumour cellscharacterises a subgroup of patients with a poorer prognosis who shouldundergo more aggressive adjuvant systemic therapy.