A histomorphometric study of cellular layers after hemiepiphyseal stapling on the physeal plate in rabbits

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• 作者：Su-Min Son (1)
  Il-Hyung Park (2)
  Chang-Wug Oh (2)
  Hyun-Joo Lee (2)
  Byung-Chul Park (2)
  Je-Yong Choi (3)
  
• 刊名：Journal of Orthopaedic Science
• 出版年：2013
• 出版时间：January 2013
• 年：2013
• 卷：18
• 期：1
• 页码：152-158
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• 作者单位：Su-Min Son (1)
  Il-Hyung Park (2)
  Chang-Wug Oh (2)
  Hyun-Joo Lee (2)
  Byung-Chul Park (2)
  Je-Yong Choi (3)
  
  1. Good-morning Hospital, 972, Dal-dong, Nam-gu, Ulsan, 680-804, Korea
  2. Department of Orthopaedic Surgery, School of Medicine, Kyugpook National University, 130 Dongduk-ro, Jung-gu, Daegu, 700-721, Korea
  3. Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, 700-422, Korea
  
• ISSN：1436-2023

文摘

Background Epiphyseal stapling has been widely used to correct angular deformity. The mechanism, however, has not been well determined. To determine the effect of temporary hemiepiphyseal stapling on the cellular layers of the physis, a histomorphometric study was performed using immature rabbits. Methods Distal lateral epiphyseal stapling of the right femur was performed on 6-week-old New Zealand white rabbits. Thirty rabbits were randomly assigned to five groups, and six rabbits in each group were analyzed weekly for up to 5?weeks. Results The distal femur was deformed into the valgus, and the anatomical lateral distal femoral angle decreased with the passage of time. In the sequential histomorphometry of the operated physeal plate, the area ratio of each layer, compared to the control side, decreased every week. The total area of the physeal plate had decreased up to 60?% at the 5th week compared to the area of the 1st week, and the area of the proliferative layer decreased by the greatest amount among the three layers. Conclusions Our findings suggest that the proliferation of chondrocytes seemed to be more suppressed by the compression of the stapling, thereby slowing the growth rate, although hypertrophy of the chondrocytes was also suppressed.