SP, CGRP changes in pyridoxine induced neuropathic dogs with nerve growth factor gene therapy

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• 作者：Joo-Yeon Kang ; Dae Young Yoo ; Kwon-Young Lee ; Wooseok Im ; Manho Kim…
• 关键词：Calcitonin gene ; related peptide ; Dog ; H reflex ; Nerve growth factor ; Pyridoxine ; Neuropathy
• 刊名：BMC Neuroscience
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：17
• 期：1
• 全文大小：8,548 KB
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• 作者单位：Joo-Yeon Kang (1)
  Dae Young Yoo (2)
  Kwon-Young Lee (3)
  Wooseok Im (4)
  Manho Kim (4)
  Jung Hoon Choi (3)
  Hwa-Young Youn (5)
  Sae Hoon Kim (6)
  In Koo Hwang (2)
  Jin-Young Chung (1)
  
  1. Department of Veterinary Internal Medicine and Geriatrics, College of Veterinary Medicine, Kangwon National University, Hyoja2-dong, Chuncheon-si, Gangwondo, 200-701, South Korea
  2. Department of Anatomy and Cell Biology, College of Veterinary Medicine, and Research Institute for Veterinary Science, Seoul National University, Gwanak-ro 599, Gwanakgu, Seoul, 151-742, South Korea
  3. Department of Anatomy, College of Veterinary Medicine, Kangwon National University, Hyoja2-dong, Chuncheon-si, Gangwondo, 200-701, South Korea
  4. Department of Neurology and Protein Metabolism Medical Research Center, College of Medicine, Seoul National University Hospital, 101 Daehakro, Chongno-ku, Seoul, 110-744, South Korea
  5. Department of Veterinary Internal Medicine, College of Veterinary Medicine, Seoul National University, Gwanak-ro 599, Gwanakgu, Seoul, 151-742, South Korea
  6. Department of Orthopedic Surgery, College of Medicine, Seoul National University Hospital, 101 Daehakro, Chongno-ku, Seoul, 110-744, South Korea
  
• 刊物主题：Neurosciences; Neurobiology; Animal Models;
• 出版者：BioMed Central
• ISSN：1471-2202

文摘

Background Nerve growth factor (NGF) is known not only as a major factor for neuronal plasticity but also as a pain stimulator. Although there have been several trials with NGF for its application in the regeneration or protection of the nervous system, the pain induced by NGF remains a challenge to be overcome. In this study, the pain induced by NGF gene therapy was evaluated.