Human U87 glioblastoma cells with stemness features display enhanced sensitivity to natural killer cell cytotoxicity through altered expression of NKG2D ligand
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- 作者：Se-Jeong Oh ; Jung-In Yang ; Ok Kim ; Eun-Jung Ahn ; Woo Dae Kang…
- 关键词：Cancer stem cells ; Glioblastoma ; Immunotherapy ; Natural killer cell ; U87
- 刊名：Cancer Cell International
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：17
- 期：1
- 全文大小：2520KB
- 刊物主题：Cancer Research; Cell Biology;
- 出版者：BioMed Central
- ISSN：1475-2867
- 卷排序：17
文摘
BackgroundGlioblastoma (GBM) is one of the most lethal tumors with a poor prognosis. Its inevitable recurrence is frequently explained by the presence of cancer stem cells. We aimed to show that human GBM cells with stemness features are more sensitive to natural killer (NK) cells than GBM cells without stemness characteristics.