Downregulation of estrogen receptor and modulation of growth of breast cancer cell lines mediated by paracrine stromal cell signals
详细信息 查看全文
- 作者：J. Huang ; P. Woods ; D. Normolle ; J. P. Goff…
- 关键词：Estrogen receptor ; HS5 cell line ; Cancer dormancy ; Estrogen receptor discordance ; Bone marrow stream cells ; Paracrine signaling ; Interleukin ; 1 ; Interleukin ; 1 receptor antagonist ; Hormone resistance ; Fulvestrant ; T47D cells ; MCF7 cells ; Dormancy ; hFob 1.19 cells
- 刊名：Breast Cancer Research and Treatment
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：161
- 期：2
- 页码：229-243
- 全文大小：
- 刊物类别：Medicine
- 刊物主题：Oncology;
- 出版者：Springer US
- ISSN：1573-7217
- 卷排序：161
文摘
PurposeBreast cancers have a poorer prognosis if estrogen receptor expression was lost during recurrence. It is unclear whether this conversion is cell autonomous or whether it can be promoted by the microenvironment during cancer dormancy. We explored the ability of marrow-derived stromal cell lines to arrest co-cultured breast cancer cells and suppress estrogen receptor alpha (ER) expression during arrest, facilitating the emergence of estrogen-independent breast cancer clones.