ADAM23 is a common risk gene for canine idiopathic epilepsy
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- 作者：Lotta L. E. Koskinen ; Eija H. Seppälä ; Jutta Weissl ; Tarja S. Jokinen…
- 关键词：Dog ; Canis familiaris ; Epilepsy ; Idiopathic epilepsy ; ADAM23 ; GWA ; Association
- 刊名：BMC Genetics
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：18
- 期：1
- 全文大小：307KB
- 刊物主题：Life Sciences, general; Animal Genetics and Genomics; Microbial Genetics and Genomics; Plant Genetics & Genomics; Genetics and Population Dynamics;
- 出版者：BioMed Central
- ISSN：1471-2156
- 卷排序：18
文摘
BackgroundIdiopathic or genetic adult-onset epilepsy is a common neurological disorder in domestic dogs. Genetic association has been reported only with ADAM23 on CFA 37 in few breeds. To identify novel epilepsy genes, we performed genome-wide association (GWA) analyses in four new breeds, and investigated the association of the previously reported ADAM23 haplotype with the epilepsy phenotype in eight breeds.