Interleukin-1B signalling leads to increased survival of gastric carcinoma cells through a CREB-C/EBPβ-associated mechanism

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• 作者：Carlos Resende ; Gonçalo Regalo ; Cecília Durães ; Marta Teixeira Pinto…
• 关键词：Helicobacter pylori ; Gastric cancer ; IL1B ; Inflammation ; Genetic susceptibility
• 刊名：Gastric Cancer
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：19
• 期：1
• 页码：74-84
• 全文大小：1,670 KB
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• 作者单位：Carlos Resende (1) (2) (3)
  Gonçalo Regalo (2)
  Cecília Durães (1) (2)
  Marta Teixeira Pinto (1) (2)
  Xiaogang Wen (4)
  Ceu Figueiredo (1) (2) (5)
  Fátima Carneiro (1) (2) (5)
  José C. Machado (1) (2) (5)
  
  1. Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal
  2. Institute of Molecular Pathology and Immunology (Ipatimup), University of Porto, Porto, Portugal
  3. Instituto de Ciências Biomédicas Abel Salazar (ICBAS), Porto, Portugal
  4. Serviço de Anatomia Patológica, Centro Hospitalar Vila Nova de Gaia/Espinho, Gaia, Portugal
  5. Faculty of Medicine, University of Porto, Porto, Portugal
  
• 刊物类别：Medicine
• 刊物主题：Medicine & Public Health
  Oncology
  Gastroenterology
  Surgical Oncology
  Pathology
  Radiotherapy
  
• 出版者：Springer Japan
• ISSN：1436-3305

文摘

Background Polymorphisms in inflammation-related genes have been associated with a risk of gastric carcinoma (GC). However, the biological mechanisms underlying these associations are still elusive. Our objective was to determine whether chronic inflammation-associated IL1Β signalling, as seen in the context of Helicobacter pylori infection, could be linked to gastric carcinogenesis by modulating the behaviour of gastric epithelial cells.