miR-508-3p concordantly silences NFKB1 and RELA to inactivate canonical NF-κB signaling in gastric carcinogenesis

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• 作者：Tingting Huang ; Wei Kang ; Bin Zhang ; Feng Wu ; Yujuan Dong…
• 关键词：NFKB1 ; RELA ; miR ; 508 ; 3p ; Gastric cancer
• 刊名：Molecular Cancer
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：15
• 期：1
• 全文大小：1,247 KB
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• 作者单位：Tingting Huang (1) (2) (3) (4)
  Wei Kang (1) (2) (3) (4)
  Bin Zhang (5)
  Feng Wu (1) (2) (3)
  Yujuan Dong (2) (4)
  Joanna H. M. Tong (1) (2) (3)
  Weiqin Yang (4) (6)
  Yuhang Zhou (1) (2) (3)
  Li Zhang (1) (2) (3)
  Alfred S. L. Cheng (4) (6)
  Jun Yu (2) (4) (7)
  Ka Fai To (1) (2) (3) (4)
  
  1. Department of Anatomical and Cellular Pathology, State Key Laboratory in Oncology in South China, Prince of Wales Hospital, The Chinese University of Hong Kong, Hong Kong, SAR, PR China
  2. Institute of Digestive Disease, Partner State Key Laboratory of Digestive Disease, The Chinese University of Hong Kong, Hong Kong, SAR, PR China
  3. Li Ka Shing Institute of Health Science, Sir Y.K. Pao Cancer Center, The Chinese University of Hong Kong, Hong Kong, SAR, PR China
  4. Shenzhen Research Institute, The Chinese University of Hong Kong, Shenzhen, PR China
  5. Department of Gastroenterology, The Affiliated Drum Tower Hospital of Nanjing University, Medical School, Nanjing, PR China
  6. School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, PR China
  7. Department of Medicine and Therapeutics, The Chinese University of Hong Kong, Hong Kong, PR China
  
• 刊物主题：Cancer Research; Oncology;
• 出版者：BioMed Central
• ISSN：1476-4598

文摘

Background NF-κB signaling pathway plays an important role in gastric carcinogenesis. The basic expression and functional role of NFKB1 and RELA (components of canonical NF-κB pathway) in gastric cancer (GC) have not been well elucidated. In this study, the role of NFKB1 and RELA in gastric tumorigenesis will be investigated and their regulation by microRNAs (miRNAs) will be deeply explored.