PPARs modulate cardiac metabolism and mitochondrial function in diabetes
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- 作者：Ting-Wei Lee ; Kuan-Jen Bai ; Ting-I Lee ; Tze-Fan Chao…
- 关键词：Cardiomyopathy ; Diabetes mellitus ; Mitochondria ; Metabolism ; Peroxisome proliferator ; activated receptors
- 刊名：Journal of Biomedical Science
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：24
- 期：1
- 全文大小：634KB
- 刊物类别：Biomedical and Life Sciences
- 刊物主题：Biomedicine, general;
- 出版者：BioMed Central
- ISSN：1423-0127
- 卷排序：24
文摘
Diabetic cardiomyopathy is a major complication of diabetes mellitus (DM). Currently, effective treatments for diabetic cardiomyopathy are limited. The pathophysiology of diabetic cardiomyopathy is complex, whereas mitochondrial dysfunction plays a vital role in the genesis of diabetic cardiomyopathy. Metabolic regulation targeting mitochondrial dysfunction is expected to be a reasonable strategy for treating diabetic cardiomyopathy. Peroxisome proliferator-activated receptors (PPARs) are master executors in regulating glucose and lipid homeostasis and also modulate mitochondrial function. However, synthetic PPAR agonists used for treating hyperlipidemia and DM have shown controversial effects on cardiovascular regulation. This article reviews our updated understanding of the beneficial and detrimental effects of PPARs on mitochondria in diabetic hearts.