Indoxyl sulfate – the uremic toxin linking hemostatic system disturbances with the prevalence of cardiovascular disease in patients with chronic kidney disease

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• 作者：Tomasz W. Kamiński ; Krystyna Pawlak ; Małgorzata Karbowska…
• 关键词：Indoxyl sulfate ; Hemostatic disorder ; Prothrombotic state ; Chronic kidney disease ; Monocytes activation ; Uremic toxin ; Tryptophan derivatives ; Tissue factor ; von Willebrand factor ; Cardiovascular disease
• 刊名：BMC Nephrology
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：18
• 期：1
• 全文大小：670KB
• 刊物主题：Nephrology; Internal Medicine;
• 出版者：BioMed Central
• ISSN：1471-2369
• 卷排序：18

文摘

BackgroundDuring chronic kidney disease progression, kidney-specific risk factors for cardiovascular disease come into play. The present study investigated the impact of indoxyl sulfate, dietary tryptophan-derived uremic toxin, accumulated in the blood of patients with chronic kidney disease on hemostatic parameters, markers of inflammation, oxidative stress and monocyte to macrophage transition.