Migraine and Inhibitory System -I Can't Hold It!
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- 作者：Caterina Mainero (1) (2)
Celine Louapre (1) (2) - 关键词：Migraine ; Pain modulation ; Disinhibition ; Brainstem ; Cortical spreading depression ; Cortical dysexcitability
- 刊名：Current Pain and Headache Reports
- 出版年：2014
- 出版时间：July 2014
- 年：2014
- 卷：18
- 期：7
- 全文大小：
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Celine Louapre (1) (2)
1. Athinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, 149 Thirteenth Street, Suite 2301, Charlestown, MA, 02129, USA
2. Harvard Medical School, Boston, MA, USA - ISSN：1534-3081
文摘
The exact pathophysiological mechanisms leading to the activation and sensitization of the trigeminovascular pathway, which in turns results in the migraine attack, are not completely elucidated. It is likely that direct activation by cortical spreading depression, together with dysfunctional central control of pain, plays a major role in the onset and spreading of the migraine attack. This review focuses on recent structural and functional neuroimaging studies that investigated the role of subcortical and cortical structures in modulating nociceptive input in migraine, which outlined the presence of an imbalance between inhibitory and excitatory modulation of pain processing in the disease.