Diagnostic performance of a new vimentin-derived ACPA (CCP high sensitive) in patients with rheumatoid arthritis

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• 作者：Daniel Bertin ; Sylvain Dubucquoi ; Daniela Lakomy…
• 关键词：Rheumatoid arthritis ; ACPA ; Anti ; CCP antibodies ; CCP hs (high sensitive) ; Anti ; citrullinated protein antibodies
• 刊名：Immunologic Research
• 出版年：2016
• 出版时间：April 2016
• 年：2016
• 卷：64
• 期：2
• 页码：455-460
• 全文大小：753 KB
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• 作者单位：Daniel Bertin (1) (2)
  Sylvain Dubucquoi (3) (4) (5)
  Daniela Lakomy (6)
  Anne-Sophie Deleplancque (3)
  Sophie Desplat-Jégo (1) (2)
  
  1. Service d’Immunologie, Pôle de Biologie, Hôpital de la Conception, Assistance Publique-Hôpitaux de Marseille, 147, Bd Baille, 13005, Marseille, France
  2. NICN UMR 7259, Aix-Marseille Université, CNRS, 13916, Marseille, France
  3. Institut d’Immunologie – Centre de Biologie Pathologie et Génétique, CHRU Lille, 59037, Lille, France
  4. LIRIC, UMR 995, INSERM, 59000, Lille, France
  5. EA 2686, Université Lille Nord de France, 59000, Lille, France
  6. Laboratoire d’Immunologie, Plateau Technique de Biologie, CHU Dijon, 21000, Dijon, France
  
• 刊物主题：Allergology; Immunology; Medicine/Public Health, general; Internal Medicine;
• 出版者：Springer US
• ISSN：1559-0755

文摘

Autoantibodies are a common feature of rheumatoid arthritis (RA), and their detection is used as a diagnostic tool in medical practice. Rheumatoid factor (RF) and/or anti-citrullinated protein antibodies (ACPA) detection in patients’ sera are now included in 2010 ACR/EULAR criteria for RA diagnosis. In this study, we evaluated a new vimentin-derived ACPA ELISA, the anti-cyclic citrullinated peptide high sensitive (CCP hs) test, and we compared its performance with the RF IgM and anti-CCP3 tests on a French multicenter cohort of 84 RA patients, 107 non-RA patients and 100 healthy controls. Sensitivities for RA diagnosis were 71.4, 84.5 and 64.3 % and specificities were 88.4, 86.9 and 87.3 % for CCP hs, CCP3 and RF IgM, respectively. There was a moderate correlation between CCP hs and CCP3 titers (Pearson’s r = 0.43; p < 0.0001). These results support the contention that anti-CCP hs antibodies are new reliable ACPA with high specificity for RA.