Inhibition of AXUD1 attenuates compression-dependent apoptosis of cementoblasts

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• 作者：Katja Korb ; Eleni Katsikogianni ; Sebastian Zingler…
• 关键词：Programmed cell death ; Tooth movement ; Root resorption ; Mechanical stress ; Periodontal ligament ; Orthodontics
• 刊名：Clinical Oral Investigations
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：20
• 期：9
• 页码：2333-2341
• 全文大小：
• 刊物类别：Medicine
• 刊物主题：Dentistry;
• 出版者：Springer Berlin Heidelberg
• ISSN：1436-3771
• 卷排序：20

文摘

ObjectivesRoot resorptions are common undesirable side effects of orthodontic treatment. In most patients, these defects are repaired by cementoblasts. However, in 1–5 % of patients, the repair fails. The repair mechanism is not well understood. Apoptosis of cementoblasts might contribute to an impaired repair of root resorptions induced by orthodontic forces.