CHADS2 and CHA2DS2-VASc scores are independently associated with incident atrial fibrillation: the Catanzaro Atrial Fibrillation Project

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• 作者：Angela Sciacqua ; Maria Perticone ; Giovanni Tripepi…
• 关键词：Atrial fibrillation ; CHADS2 score ; CHA2DS2 ; VASc score ; Cardiovascular risk factors
• 刊名：Internal and Emergency Medicine
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：10
• 期：7
• 页码：815-821
• 全文大小：491 KB
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• 作者单位：Angela Sciacqua (1)
  Maria Perticone (2)
  Giovanni Tripepi (3)
  Eliezer J. Tassone (1)
  Antonio Cimellaro (1)
  Deborah Mazzaferro (1)
  Giorgio Sesti (1)
  Francesco Perticone (1)
  
  1. Department of Medical and Surgical Sciences, University Magna Gr?cia of Catanzaro, Campus Universitario di Germaneto, V.le Europa, 88100, Catanzaro, Italy
  2. Department of Clinical and Experimental Medicine, University Magna Graecia of Catanzaro, Catanzaro, Italy
  3. Consiglio Nazionale delle Ricerche, Istituto di Biomedicina, Clinical Epidemiology and Physiopathology of Renal Diseases and Hypertension, Reggio Calabria, Italy
  
• 刊物主题：Internal Medicine;
• 出版者：Springer Milan
• ISSN：1970-9366

文摘

No data exist concerning a possible association between CHADS₂ or CHA₂DS₂-VASc scores and atrial fibrillation (AF). In this prospective observational study, we tested the hypothesis whether thromboembolic risk scores predict AF. We investigated 3549 subjects, 1829 men and 1720 women, aged 60.7 ± 10.6 years, without baseline AF. Patients with thyroid disorders were excluded. CHADS₂ and CHA₂DS₂-VASc scores were evaluated as categorical variables. To test the effect of some clinical confounders on incident AF, we constructed different models including clinical and laboratory parameters. During follow-up (53.3 ± 18.1 months), 546 subjects developed AF (4.5 events/100 patient-years). Progressors to AF are older, have a higher body mass index (BMI), blood pressure, LDL-cholesterol, and glucose. Hypertension, metabolic syndrome, diabetes and carotid wall thickening were more common among AF cases than among control subjects. In the final Cox-regression model, variables that remained significantly associated with incident AF were BMI (HR = 1.022, 95 % CI = 1.008-.037), LDL-cholesterol (HR = 1.032, 95 % CI = 1.008-.056), CHA₂DS₂-VASc score (HR = 1.914, 95 % CI = 1.439-.546), and CHADS₂ score (HR = 2.077, 95 % CI = 1.712-.521). In conclusion, CHADS₂ and CHA₂DS₂-VASc scores are independent predictors of AF. Keywords Atrial fibrillation CHADS₂ score CHA₂DS₂-VASc score Cardiovascular risk factors