Protein overexpression of CIRP and TLR4 in oral squamous cell carcinoma: an immunohistochemical and clinical correlation analysis
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- 作者：Wen Hao Ren (1)
Lin Mei Zhang (1)
Huai Qin Liu (3)
Ling Gao (1) (2)
Cheng Chen (1)
Cui Qiang (1)
Xiao Long Wang (1)
Chang Yang Liu (1)
Shao Ming Li (1)
Chen Huang (2)
Hong Qi (1)
Ke Qian Zhi (1) - 关键词：CIRP ; TLR4 ; OSCC ; IHC ; Prognosis
- 刊名：Medical Oncology
- 出版年：2014
- 出版时间：August 2014
- 年：2014
- 卷：31
- 期：8
- 全文大小：1,192 KB
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Lin Mei Zhang (1)
Huai Qin Liu (3)
Ling Gao (1) (2)
Cheng Chen (1)
Cui Qiang (1)
Xiao Long Wang (1)
Chang Yang Liu (1)
Shao Ming Li (1)
Chen Huang (2)
Hong Qi (1)
Ke Qian Zhi (1)
1. Department of Oral and Maxillofacial Surgery, College of Stomatology, Xi鈥檃n Jiaotong University, Number 98, Xiwu Road, Xi鈥檃n, 710004, Shaanxi, People鈥檚 Republic of China
3. Department of Stomatology, The First Hospital of Yulin, Yulin, 718000, Shaanxi, People鈥檚 Republic of China
2. Key Laboratory of Environment and Genes Related to Diseases, College of Medicine, Xi鈥檃n Jiaotong University, Xi鈥檃n, 710061, Shaanxi, People鈥檚 Republic of China - ISSN：1559-131X
文摘
Oral squamous cell carcinoma (OSCC) is the most common head and neck malignancy. Here, we evaluated the expression of cold-inducible RNA-binding protein (CIRP) and toll-like receptors 4 (TLR4) in OSCC tissues with immunohistochemistry. Using biostatistical methods designed to assess the impact of the expression of CIRP and TLR4 on the prognosis of patients with OSCC and relate that expression to the clinicopathological characteristics of these patients. For the first time, we demonstrated that the expression of CIRP and TLR4 was increased in OSCC and that high levels of CIRP or TLR4 expression were associated with a short survival rate. In addition, we were surprised to find that the levels of expression of CIRP and TLR4 were very similar. The goal of this study was to evaluate whether these two genes may provide clues as to the regulatory mechanisms of OSCC, serve as prognostic markers and establish a new direction for further studies of these biological mechanisms.