Glucose transporter 4 promotes head and neck squamous cell carcinoma metastasis through the TRIM24-DDX58 axis
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- 作者：Yu-Chan Chang ; Li-Hsing Chi ; Wei-Ming Chang ; Chia-Yi Su…
- 关键词：GLUT4 ; HNSCC ; TRIM24 ; DDX58 ; Metastasis
- 刊名：Journal of Hematology & Oncology
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：10
- 期：1
- 全文大小：5655KB
- 刊物主题：Oncology; Hematology; Cancer Research;
- 出版者：BioMed Central
- ISSN：1756-8722
- 卷排序：10
文摘
BackgroundHead and neck squamous cell carcinoma (HNSCC) represents a unique and major health concern worldwide. Significant increases in glucose uptake and aerobic glycolysis have been observed in HNSCC cells. Glucose transporters (GLUTs) represent a major hub in the glycolysis pathway, with GLUT4 having the highest glucose affinity. However, GLUT4’s role in HNSCC has not been fully appreciated.