Synthesis of tricyclic quinazolinones via intramolecular cyclization of 3-(2-aminoalkyl)-2-(phenylamino)quinazolin-4(3H)-ones

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• 作者：Xuhong Yang ; Minghu Wu ; Shaofa Sun ; Changfeng Huang ; Haibing Guo…
• 关键词：Tricyclic quinazoline ; Intramolecular cyclization ; Guanidines
• 刊名：Molecular Diversity
• 出版年：2016
• 出版时间：May 2016
• 年：2016
• 卷：20
• 期：2
• 页码：551-556
• 全文大小：878 KB
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  7.Chern JW, Liaw YC, Chen CS, Rong JG, Huang CL, Chan CH, Wang AHJ (1993) studies on 1,2,4-benzothiadiazine 1,1-dioxides-vii and quinazolinones-iv-synthesis of novel built-in hydroxyguanidine tricycles as potential anticancer agents. Heterocycles 36:1091–1103CrossRef
  8.Jen T, Dienel B, Bowman H, Petta J, Helt A, Loev B (1972) Amidines. 2. New class of antihypertensive agents. 1,2,3,5-Tetrahydroimidazo[2,1-b]quinazolines. J Med Chem 15:727–731. doi:10.​1021/​jm00277a008 CrossRef PubMed
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  11.Larraufie MH, Ollivier C, Fensterbank L, Malacria M, Lacote E (2009) Radical synthesis of guanidines from N-Acyl cyanamides. Angew Chem Int Ed 49:2178–2181. doi:10.​1002/​anie.​200907237 CrossRef
  12.Yin P, Liu N, Deng YX, Chen Y, Deng Y, He L (2012) Synthesis of 2,4-diaminoquinazolines and tricyclic quinazolines by cascade reductive cyclization of methyl N-cyano-2-nitrobenzimidates. J Org Chem 77:2649–2658. doi:10.​1021/​jo2023697 CrossRef PubMed
  13.Yang XH, Wu MH, Sun SF, Ding MW, Xie JL, Xia QH (2008) Synthesis of 3-aminoalkyl-2-arylaminoquiazolin-4(3H)-ones and 3,3’-disubstituted bis-2-arylaminoquinazolin-4(3H)-ones via reactions of 1-aryl-3-(2-ethoxycarbonylphenyl)carbodiimides with diamines. J Heterocycl Chem 45:1365–1369. doi:10.​1002/​jhet.​5570450518 CrossRef
  14.Yang X, Wu M, Ding M (2010) Synthesis of 2,2 -disubstituted bis(3-arylquinazolin-4(3H)-one)s. Chin J Org Chem 30:1032–1038
  15.Wu MH, Hu JH, Shen DS, Bremond P, Guo H (2010) Regiospecific synthesis of 6-aryl-3-cyano-5-alkylamino/arylamino-1-p-tolyl-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-ones via iminophosphorane-mediated annulation. Tetrahedron 66:5112–5120. doi:10.​1016/​j.​tet.​2010.​04.​114 CrossRef
  16.Wu MH, Hu JH, Guo HB, Li Y (2012) A facile and efficient one-pot three-step protocol for synthesis of 6-aryl-7-oxo-5-aryoxy/alkoxy-1-(p-tolyl)-6,7-dihydro-1H-pyrazolo[4,3-d]pyrimidine-3-carbonitrile. Arkivoc VI:295–303
  
• 作者单位：Xuhong Yang (1)
  Minghu Wu (1)
  Shaofa Sun (1)
  Changfeng Huang (2)
  Haibing Guo (1)
  Jian Wang (1)
  John Lee (3)
  Yalan Xing (3)
  
  1. Hubei Collaborative Innovation Centre for Non-power Nuclear Technology, College of Neuclear Technology & Chemistry and Biology, Hubei University of Science and Technology, Xianning, 437100, China
  2. Bennett Department of Chemistry, West Virginia University, Morgantown, WV, 26506, USA
  3. Department of Chemistry, William Paterson University, 300 Pompton Rd, Wayne, NJ, 07470, USA
  
• 刊物类别：Chemistry and Materials Science
• 刊物主题：Chemistry
  Analytical Chemistry
  Polymer Sciences
  Organic Chemistry
  Pharmacy
  
• 出版者：Springer Netherlands
• ISSN：1573-501X

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