Evaluation of right ventricular volume and ejection fraction by gated 18F-FDG PET in patients with pulmonary hypertension: Comparison with cardiac MRI and CT

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• 作者：Lei Wang MD (1)
  Yan Zhang MD (2)
  Chaowu Yan MD (2)
  Jianguo He MD (3)
  Changming Xiong MD (3)
  Shihua Zhao MD (2)
  Wei Fang MD (1)
  
• 关键词：Right ventricular function ; gated 18F ; FDG PET myocardial imaging ; cardiac magnetic resonance ; cardiac computed tomography ; pulmonary hypertension
• 刊名：Journal of Nuclear Cardiology
• 出版年：2013
• 出版时间：April 2013
• 年：2013
• 卷：20
• 期：2
• 页码：242-252
• 全文大小：558KB
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• 作者单位：Lei Wang MD (1)
  Yan Zhang MD (2)
  Chaowu Yan MD (2)
  Jianguo He MD (3)
  Changming Xiong MD (3)
  Shihua Zhao MD (2)
  Wei Fang MD (1)
  
  1. Department of Nuclear Medicine, Cardiovascular Institute and Fu Wai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, 167 Beilishi Road, Beijing, 100037, China
  2. Department of Radiology, Cardiovascular Institute and Fu Wai Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100037, China
  3. Center for Diagnosis and Management of Pulmonary Vascular Diseases, Department of Cardiology, Cardiovascular Institute and Fu Wai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100037, China
  

文摘

Background Right ventricular (RV) function is a powerful predictor of survival in patients with pulmonary hypertension (PH), but noninvasively assessing RV function remains a challenge. The aim of this study was to prospectively compare gated 18F-fluorodeoxyglucose positron emission tomography (18F-FDG PET) myocardial imaging (gated PET), cardiac magnetic resonance (CMR), and cardiac computed tomography (CCT) for the assessment of RV volume and ejection fraction in patients with PH. Methods Twenty-three consecutive patients aged more than 16?years diagnosed with PH were included. All patients underwent gated PET, CMR, and CCT within 7?days. Right ventricular end-diastolic volume (RVEDV), right ventricular end-systolic volume (RVESV), and right ventricular ejection fraction (RVEF) were calculated by three imaging modalities. RV 18F-FDG uptake was determined as RV-corrected standardized uptake value (SUV), and the ratio of RV to left ventricular (LV)-corrected SUV (Corrected SUV R/L). Results Gated PET showed a moderate correlation (r?=?0.680, P?<?.001) for RVEDV, good correlation for RVESV (r?=?0.757, P?<?.001) and RVEF (r?=?0.788, P?<?.001) with CMR, and good correlation for RVEDV (r?=?0.767, P?<?.001), RVESV (r?=?0.837, P?<?.001), and RVEF (r?=?0.730, P?<?.001) with CCT. Bland-Altman analysis revealed systematic underestimation of RVEDV and RVESV and overestimation of RVEF with gated PET compared with CMR and CCT. The correlation between RVESV (r?=?0.863, P?<?.001), RVESV (r?=?0.903, P?<?.001), and RVEF (r?=?0.853, P?<?.001) of CMR and those of CCT was excellent; Bland-Altman analysis showed only a slight systematic variation between CMR and CCT. There were statistically significant negative correlations between RV-corrected SUV and RVEF-CMR (r?=??.543, P?<?.01), Corrected SUV R/L and RVEF-CMR (r?=??.521, P?<?.05), RV-corrected SUV and RVEF-CCT (r?=??.429, P?<?.05), Corrected SUV R/L and RVEF-CCT (r?=??.580, P?<?.01), respectively. Conclusion Gated PET had moderate-to-high correlation with CMR and CCT in the assessments of RV volume and ejection fraction. It is an available method for simultaneous assessing of RV function and myocardial glucose metabolism in patients with PH.