Molecular functions and significance of the MTA family in hormone-independent cancer

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• 作者：Zhifeng Ning (1) (2) (3)
  Jinfeng Gan (3)
  Chaoying Chen (3)
  Dianzheng Zhang (4)
  Hao Zhang (2) (3) (5)
  
• 关键词：Metastasis ; associated proteins ; NuRD ; Hormone ; independent cancers ; Prognosis ; Therapeutic targets
• 刊名：Cancer and Metastasis Reviews
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：33
• 期：4
• 页码：901-919
• 全文大小：1,101 KB
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• 作者单位：Zhifeng Ning (1) (2) (3)
  Jinfeng Gan (3)
  Chaoying Chen (3)
  Dianzheng Zhang (4)
  Hao Zhang (2) (3) (5)
  
  1. Laboratory for Translational Oncology, Basic Medicine College, Hubei University of Science and Technology, Xianning, Hubei Province, 437100, China
  2. Department of Biotherapy and Gastrointestinal Medical Oncology, Affiliated Cancer Hospital of Shantou University Medical College, 7 Raoping Road, Shantou, Guangdong Province, 515041, China
  3. Cancer Research Center, Shantou University Medical College, 22 Xinling Road, Shantou, Guangdong Province, 515041, China
  4. Department of Biochemistry and Molecular Biology and Center for Chronic Disorders of Aging, Philadelphia College of Osteopathic Medicine, Philadelphia, PA, 19131, USA
  5. Guangdong Provincial Key Lab for Breast Cancer Diagnosis & Treatment, Affiliated Cancer Hospital of Shantou University Medical College, 7 Raoping Road, Shantou, Guangdong Province, 515041, China
  
• ISSN：1573-7233

文摘

The members of the metastasis-associated protein (MTA) family play pivotal roles in both physiological and pathophysiological processes, especially in cancer development and metastasis, and their role as master regulators has come to light. Due to the fact that they were first identified as crucial factors in estrogen receptor-mediated breast cancer metastasis, most of the early studies focused on their hormone-dependent functions. However, the accumulating evidence shows that the members of MTA family are deregulated in most, if not all, the cancers studied so far. Therefore, the levels as well as the activities of the MTA family members are widely accepted as potential biomarkers for diagnosis, prognosis, and predictors of overall survival. They function differently in different cancers with specific mechanisms. p53 and HIF-1α appear to be the respectively common upstream and downstream regulator of the MTA family in both development and metastasis of a wide spectrum of cancers. Here, we review the expression and clinical significance of the MTA family, focusing on hormone-independent cancers. To illustrate the molecular mechanisms, we analyze the MTA family-related signaling pathways in different cancers. Finally, targeting the MTA family directly or the pathways involved in the MTA family indirectly could be invaluable strategies in the development of cancer therapeutics.