Use of liposomal doxorubicin for adjuvant chemotherapy of breast cancer in clinical practice

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• 作者：Ming Zhao ; Xian-feng Ding ; Jian-yu Shen…
• 关键词：Key wordsLiposomal doxorubicin ; Breast cancer ; Adjuvant chemotherapy ; Therapeutic effect ; Toxic and side effects
• 刊名：Journal of Zhejiang University-SCIENCE B
• 出版年：2017
• 出版时间：January 2017
• 年：2017
• 卷：18
• 期：1
• 页码：15-26
• 全文大小：
• 刊物主题：Biomedicine, general;
• 出版者：Zhejiang University Press
• ISSN：1862-1783
• 卷排序：18

文摘

Breast cancer is one of the malignant tumors with the highest morbidity and mortality. It is helpful to reduce the rate of tumor recurrence and metastasis by treating breast cancer with adjuvant chemotherapy, so as to increase the cure rate or survival of patients. In recent years, liposomes have been regarded as a kind of new carrier for targeted drugs. Being effective for enhancing drug efficacy and reducing side effects, they have been widely used for developing anticancer drugs. As a kind of anthracycline with high anticancer activity, doxorubicin can treat or alleviate a variety of malignant tumors effectively when it is used on its own or in combination with other anticancer drugs. Although liposomal doxorubicin has been extensively used in the adjuvant chemotherapy of breast cancer, its exact therapeutic efficacy and side effects have not been definitely proven. Various clinical studies have adopted different combined regimes, dosages, and staging, so their findings differ to certain extent. This paper reviews the clinical application of liposomal doxorubicin in the adjuvant chemotherapy of breast cancer and illustrates therapeutic effects and side effects of pegylated liposomal doxorubicin (PLD) and non-PLD (NPLD) in clinical research, in order to discuss the strategies for applying these drugs in such adjuvant chemotherapy, looking forward to providing references for related research and clinical treatment in terms of dosage, staging, combined regimes, and analysis methods and so on.