APPL1 prevents pancreatic beta cell death and inflammation by dampening NFκB activation in a mouse model of type 1 diabetes

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• 作者：Xue Jiang ; Yawen Zhou ; Kelvin K. L. Wu ; Zhanrui Chen ; Aimin Xu…
• 关键词：APPL1 ; Beta cell apoptosis ; Beta cell inflammation ; NFκB ; Streptozotocin ; Type 1 diabetes
• 刊名：Diabetologia
• 出版年：2017
• 出版时间：March 2017
• 年：2017
• 卷：60
• 期：3
• 页码：464-474
• 全文大小：<len>
• 刊物类别：Medicine
• 刊物主题：Internal Medicine; Metabolic Diseases; Human Physiology;
• 出版者：Springer Berlin Heidelberg
• ISSN：1432-0428
• 卷排序：60

文摘

Aims/hypothesisBeta cell inflammation and demise is a feature of type 1 diabetes. The insulin-sensitising molecule ‘adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1’ (APPL1), which contains an NH₂-terminal Bin/Amphiphysin/Rvs domain, a central pleckstrin homology domain and a COOH-terminal phosphotyrosine-binding domain, has been shown to modulate inflammatory response in various cell types but its role in regulating beta cell mass and inflammation in type 1 diabetes remains unknown. Thus, we investigated whether APPL1 prevents beta cell apoptosis and inflammation in diabetes.