Synthesis and antibacterial evaluation of novel Schiff base derivatives containing 4(3H)-quinazolinone moiety
详细信息 查看全文
- 作者：Mei-Hang Chen ; Xiao-Bing Wang ; Bang-Cheng Tang ; Xun Zhang
- 关键词：KeywordSchiff base derivatives ; 4(3H) ; quinazolinone ; synthesis ; antibacterial activity
- 刊名：Chemical Papers
- 出版年：2016
- 出版时间：November 2016
- 年：2016
- 卷：70
- 期：11
- 页码：1521-1528
- 全文大小：
- 刊物类别：Chemistry and Materials Science
- 刊物主题：Chemistry/Food Science, general; Industrial Chemistry/Chemical Engineering; Biochemistry, general; Medicinal Chemistry; Materials Science, general; Biotechnology;
- 出版者：Springer International Publishing
- ISSN：1336-9075
- 卷排序：70
文摘
A series of novel Schiff base derivatives containing 4(3H)-quinazolinone moiety were synthesised and their antibacterial activities against tobacco and tomato bacterial wilts evaluated in vitro. Out of the synthesised compounds, 5g, 5j, 5n, 5m and 5p exhibited excellent antibacterial activities against tobacco bacterial wilt, with half maximal effective concentrations (EC50): 160.34, 158.03, 125.94, 148.09 and 133.67 (all in εg mL−1), respectively, which were better than the EC50 of thiodiazole–copper (216.70 εg mL−1). Compounds 5j, 5n and 5o also showed good antibacterial activities against tomato bacterial wilt, with EC50 of 95.20, 90.03 and 83.21 (all in εg mL−1) respectively, which were better than the EC50of thiodiazole–copper (99.80 εg mL−1). These compounds may prove to be useful as potential antibacterial agents.