Constructing backbone network by using tinker algorithm

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• 作者：Zhiwei He ; Meng Zhan ; Jianxiong Wang ; Chenggui Yao
• 关键词：biological network ; backbone network ; tinker algorithm ; mathematical model
• 刊名：Frontiers of Physics
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：12
• 期：6
• 页码：1-15
• 全文大小：
• 刊物类别：Physics and Astronomy
• 刊物主题：Atomic, Molecular, Optical and Plasma Physics; Condensed Matter Physics; Particle and Nuclear Physics; Astronomy, Astrophysics and Cosmology;
• 出版者：Higher Education Press
• ISSN：2095-0470
• 卷排序：12

文摘

Revealing how a biological network is organized to realize its function is one of the main topics in systems biology. The functional backbone network, defined as the primary structure of the biological network, is of great importance in maintaining the main function of the biological network. We propose a new algorithm, the tinker algorithm, to determine this core structure and apply it in the cell-cycle system. With this algorithm, the backbone network of the cell-cycle network can be determined accurately and efficiently in various models such as the Boolean model, stochastic model, and ordinary differential equation model. Results show that our algorithm is more efficient than that used in the previous research. We hope this method can be put into practical use in relevant future studies.