Ring finger protein 39 genetic variants associate with HIV-1 plasma viral loads and its replication in cell culture

详细信息    查看全文

• 作者：Ying-Ju Lin (1) (2)
  Chia-Yen Chen (3)
  Kuan-Teh Jeang (4)
  Xiang Liu (4)
  Jen-Hsien Wang (5)
  Chien-Hui Hung (6)
  Hsinyi Tsang (7)
  Ting-Hsu Lin (1)
  Chiu-Chu Liao (1)
  Shao-Mei Huang (1)
  Cheng-Wen Lin (8)
  Mao-Wang Ho (5)
  Wen-Kuei Chien (10) (9)
  Jin-Hua Chen (10) (9)
  Tsung-Jung Ho (11) (12) (2)
  Fuu-Jen Tsai (1) (13) (2)
  
  1. Genetic Center ; Department of Medical Research ; China Medical University Hospital ; Taichung ; Taiwan
  2. School of Chinese Medicine ; China Medical University ; Taichung ; Taiwan
  3. Viral Biochemistry Section ; Laboratory of Molecular Microbiology ; National Institute of Allergy and Infectious Diseases ; National Institutes of Health ; Bethesda ; Maryland ; USA
  4. Molecular Virology Section ; Laboratory of Molecular Microbiology ; National Institute of Allergy and Infectious Diseases ; National Institutes of Health ; Bethesda ; Maryland ; USA
  5. Section of Infectious Diseases ; Department of Internal Medicine ; China Medical University Hospital ; Taichung ; Taiwan
  6. Graduate Institute of Clinical Medical Science ; Chang-Gung University ; Chiayi ; Taiwan
  7. The Laboratory of Molecular Immunogenetics ; National Institute of Allergy and Infectious Diseases ; National Institutes of Health ; Bethesda ; MD ; USA
  8. Department of Medical Laboratory Science and Biotechnology ; China Medical University ; Taichung ; Taiwan
  10. Biostatistics Center ; Taipei Medical University ; Taipei ; Taiwan
  9. Biostatistics Center ; China Medical University ; Taichung ; Taiwan
  11. Division of Chinese Medicine ; China Medical University Beigang Hospital ; Yunlin County ; Taiwan
  12. Division of Chinese Medicine ; Tainan Municipal An-Nan Hospital -China Medical University ; Tainan ; Taiwan
  13. Department of Biotechnology ; Asia University ; Taichung ; Taiwan
  
• 关键词：HIV ; 1 viral load ; RNF39 ; Single nucleotide polymorphism ; Viral replication
• 刊名：Cell & Bioscience
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：4
• 期：1
• 全文大小：947 KB
• 参考文献：1. Friedrich, BM, Dziuba, N, Li, G, Endsley, MA, Murray, JL, Ferguson, MR (2011) Host factors mediating HIV-1 replication. Virus Res 161: pp. 101-114 CrossRef
  2. Arhel, N, Kirchhoff, F (2010) Host proteins involved in HIV infection: new therapeutic targets. Biochim Biophys Acta 1802: pp. 313-321 CrossRef
  3. Strebel, K, Luban, J, Jeang, KT (2009) Human cellular restriction factors that target HIV-1 replication. BMC Med 7: pp. 48 CrossRef
  4. Perez, O, Hope, TJ (2006) Cellular restriction factors affecting the early stages of HIV replication. Curr HIV/AIDS Rep 3: pp. 20-25 CrossRef
  5. Goff, SP (2007) Host factors exploited by retroviruses. Nat Rev Microbiol 5: pp. 253-263 CrossRef
  6. Chen, CY, Liu, X, Boris-Lawrie, K, Sharma, A, Jeang, KT (2013) Cellular RNA helicases and HIV-1: insights from genome-wide, proteomic, and molecular studies. Virus Res 171: pp. 357-365 CrossRef
  7. Brass, AL, Dykxhoorn, DM, Benita, Y, Yan, N, Engelman, A, Xavier, RJ, Lieberman, J, Elledge, SJ (2008) Identification of host proteins required for HIV infection through a functional genomic screen. Science 319: pp. 921-926 CrossRef
  8. Zhou, H, Xu, M, Huang, Q, Gates, AT, Zhang, XD, Castle, JC, Stec, E, Ferrer, M, Strulovici, B, Hazuda, DJ, Espeseth, AS (2008) Genome-scale RNAi screen for host factors required for HIV replication. Cell Host Microbe 4: pp. 495-504 CrossRef
  9. Konig, R, Zhou, Y, Elleder, D, Diamond, TL, Bonamy, GM, Irelan, JT, Chiang, CY, Tu, BP, De Jesus, PD, Lilley, CE, Seidel, S, Opaluch, AM, Caldwell, JS, Weitzman, MD, Kuhen, KL, Bandyopadhyay, S, Ideker, T, Orth, AP, Miraglia, LJ, Bushman, FD, Young, JA, Chanda, SK (2008) Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. Cell 135: pp. 49-60 CrossRef
  10. Yeung, ML, Houzet, L, Yedavalli, VS, Jeang, KT (2009) A genome-wide short hairpin RNA screening of jurkat T-cells for human proteins contributing to productive HIV-1 replication. J Biol Chem 284: pp. 19463-19473 CrossRef
  11. Fellay, J, Shianna, KV, Ge, D, Colombo, S, Ledergerber, B, Weale, M, Zhang, K, Gumbs, C, Castagna, A, Cossarizza, A, Cozzi-Lepri, A, De Luca, A, Easterbrook, P, Francioli, P, Mallal, S, Martinez-Picado, J, Miro, JM, Obel, N, Smith, JP, Wyniger, J, Descombes, P, Antonarakis, SE, Letvin, NL, McMichael, AJ, Haynes, BF, Telenti, A, Goldstein, DB (2007) A whole-genome association study of major determinants for host control of HIV-1. Science 317: pp. 944-947 CrossRef
  12. van Manen, D, Kootstra, NA, Boeser-Nunnink, B, Handulle, MA, van鈥檛 Wout, AB, Schuitemaker, H (2009) Association of HLA-C and HCP5 gene regions with the clinical course of HIV-1 infection. AIDS 23: pp. 19-28 CrossRef
  13. Lin, YJ, Lan, YC, Hung, CH, Lin, TH, Huang, SM, Liao, CC, Lin, CW, Lai, CH, Tien, N, Liu, X, Ho, MW, Chien, WK, Chen, JH, Wang, JH, Tsai, FJ (2013) Variants in ZNRD1 gene predict HIV-1/AIDS disease progression in a Han Chinese population in Taiwan. PLoS One 8: pp. e67572 CrossRef
  14. Matsuo, R, Asada, A, Fujitani, K, Inokuchi, K (2001) LIRF, a gene induced during hippocampal long-term potentiation as an immediate-early gene, encodes a novel RING finger protein. Biochem Biophys Res Commun 289: pp. 479-484 CrossRef
  15. Hung, CH, Thomas, L, Ruby, CE, Atkins, KM, Morris, NP, Knight, ZA, Scholz, I, Barklis, E, Weinberg, AD, Shokat, KM, Thomas, G (2007) HIV-1 Nef assembles a Src family kinase-ZAP-70/Syk-PI3K cascade to downregulate cell-surface MHC-I. Cell Host Microbe 1: pp. 121-133 CrossRef
  16. Fellay, J, Ge, D, Shianna, KV, Colombo, S, Ledergerber, B, Cirulli, ET, Urban, TJ, Zhang, K, Gumbs, CE, Smith, JP, Castagna, A, Cozzi-Lepri, A, De Luca, A, Easterbrook, P, Gunthard, HF, Mallal, S, Mussini, C, Dalmau, J, Martinez-Picado, J, Miro, JM, Obel, N, Wolinsky, SM, Martinson, JJ, Detels, R, Margolick, JB, Jacobson, LP, Descombes, P, Antonarakis, SE, Beckmann, JS, O鈥橞rien, SJ (2009) Common genetic variation and the control of HIV-1 in humans. PLoS Genet 5: pp. e1000791 CrossRef
  17. Trachtenberg, E, Bhattacharya, T, Ladner, M, Phair, J, Erlich, H, Wolinsky, S (2009) The HLA-B/-C haplotype block contains major determinants for host control of HIV. Genes Immun 10: pp. 673-677 CrossRef
  18. Ballana, E, Senserrich, J, Pauls, E, Faner, R, Mercader, JM, Uyttebroeck, F, Palou, E, Mena, MP, Grau, E, Clotet, B, Ruiz, L, Telenti, A, Ciuffi, A, Este, JA (2010) ZNRD1 (zinc ribbon domain-containing 1) is a host cellular factor that influences HIV-1 replication and disease progression. Clin Infect Dis 50: pp. 1022-1032 CrossRef
  19. Biris, N, Tomashevski, A, Bhattacharya, A, Diaz-Griffero, F, Ivanov, DN (2013) Rhesus monkey TRIM5alpha SPRY domain recognizes multiple epitopes that span several capsid monomers on the surface of the HIV-1 mature viral core. J Mol Biol 425: pp. 5032-5044 CrossRef
  20. Li, X, Kim, J, Song, B, Finzi, A, Pacheco, B, Sodroski, J (2013) Virus-specific effects of TRIM5alpha(rh) RING domain functions on restriction of retroviruses. J Virol 87: pp. 7234-7245 CrossRef
  21. Kovalskyy, DB, Ivanov, DN (2014) Recognition of the HIV capsid by the TRIM5alpha restriction factor is mediated by a subset of pre-existing conformations of the TRIM5alpha SPRY domain. Biochemistry 53: pp. 1466-1476 CrossRef
  22. Sherry, ST, Ward, MH, Kholodov, M, Baker, J, Phan, L, Smigielski, EM, Sirotkin, K (2001) dbSNP: the NCBI database of genetic variation. Nucleic Acids Res 29: pp. 308-311 CrossRef
  23. Sherry, ST, Ward, M, Sirotkin, K (2000) Use of molecular variation in the NCBI dbSNP database. Hum Mutat 15: pp. 68-75 CrossRef
  24. Barrett, JC, Fry, B, Maller, J, Daly, MJ (2005) Haploview: analysis and visualization of LD and haplotype maps. Bioinformatics 21: pp. 263-265 CrossRef
  25. Tindall, EA, Petersen, DC, Nikolaysen, S, Miller, W, Schuster, SC, Hayes, VM (2010) Interpretation of custom designed Illumina genotype cluster plots for targeted association studies and next-generation sequence validation. BMC Res Notes 3: pp. 39 CrossRef
  26. Gabriel, SB, Schaffner, SF, Nguyen, H, Moore, JM, Roy, J, Blumenstiel, B, Higgins, J, DeFelice, M, Lochner, A, Faggart, M, Liu-Cordero, SN, Rotimi, C, Adeyemo, A, Cooper, R, Ward, R, Lander, ES, Daly, MJ, Altshuler, D (2002) The structure of haplotype blocks in the human genome. Science 296: pp. 2225-2229 CrossRef
  27. Stephens, M, Smith, NJ, Donnelly, P (2001) A new statistical method for haplotype reconstruction from population data. Am J Hum Genet 68: pp. 978-989 CrossRef
  28. Stephens, M, Donnelly, P (2003) A comparison of bayesian methods for haplotype reconstruction from population genotype data. Am J Hum Genet 73: pp. 1162-1169 CrossRef
  29. Liu, X, Du, L, Feng, R (2013) c-Src regulates cell cycle proteins expression through protein kinase B/glycogen synthase kinase 3 beta and extracellular signal-regulated kinases 1/2 pathways in MCF-7 cells. Acta Biochim Biophys Sin (Shanghai) 45: pp. 586-592 CrossRef
  30. Tang, SW, Chen, CY, Klase, Z, Zane, L, Jeang, KT (2012) The cellular autophagy pathway modulates HTLV-1 replication. J Virol 87: pp. 1699-1707 CrossRef
  31. Zane, L, Yasunaga, J, Mitagami, Y, Yedavalli, V, Tang, SW, Chen, CY, Ratner, L, Lu, X, Jeang, KT (2012) Wip1 and p53 contribute to HTLV-1 Tax-induced tumorigenesis. Retrovirology 9: pp. 114 CrossRef
  32. Zhang, Q, Jeang, KT (2013) Long noncoding RNAs and viral infections. BioMedicine 3: pp. 34-42 CrossRef
  33. Liu, X, Feng, R (2010) Inhibition of epithelial to mesenchymal transition in metastatic breast carcinoma cells by c-Src suppression. Acta Biochim Biophys Sin (Shanghai) 42: pp. 496-501 CrossRef
  34. Liu, X, Feng, R, Du, L (2010) The role of enoyl-CoA hydratase short chain 1 and peroxiredoxin 3 in PP2-induced apoptosis in human breast cancer MCF-7 cells. FEBS Lett 584: pp. 3185-3192 CrossRef
  
• 刊物主题：Cell Biology; Microbiology;
• 出版者：BioMed Central
• ISSN：2045-3701

文摘

Background The human immunodeficiency virus (HIV-1) exploits host proteins to complete its life cycle. Genome-wide siRNA approaches suggested that host proteins affect HIV-1 replication. However, the results barely overlapped. RING finger protein 39 (RNF39) has been identified from genome-wide association studies. However, its function during HIV-1 replication remains unclear. Methods and results We investigated the relationship between common RNF39 genetic variants and HIV-1 viral loads. The effect of RNF39 protein knockdown or overexpression on HIV-1 replication was then investigated in different cell lines. Two genetic variants were associated with HIV-1 viral loads. Patients with the ht1-GG/GG haplotype presented lower RNF39 expression levels and lower HIV-1 viral load. RNF39 knockdown inhibited HIV-1 expression. Conclusions RNF39 protein may be involved in HIV-1 replication as observed in genetic studies on patients with HIV-1 and in in vitro cell cultures.