Neurotrophic Tyrosine Kinase Receptor Type 2 (NTRK2) Gene Associated with Treatment Response to Mood Stabilizers in Patients with Bipolar I Disorder

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• 作者：Zuowei Wang (1) (2)
  Jinbo Fan (3) (4)
  Keming Gao (4)
  Zezhi Li (1)
  Zhenghui Yi (1)
  Lingxiao Wang (1)
  Jia Huang (1)
  Chengmei Yuan (1)
  Wu Hong (1)
  Shunying Yu (5)
  Yiru Fang (1)
  
• 关键词：Bipolar disorder ; Brain ; derived neurotrophic factor (BDNF) ; Neurotrophic tyrosine kinase receptor type 2 (NTRK2) ; Polymorphism ; Association
• 刊名：Journal of Molecular Neuroscience
• 出版年：2013
• 出版时间：June 2013
• 年：2013
• 卷：50
• 期：2
• 页码：305-310
• 全文大小：125KB
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• 作者单位：Zuowei Wang (1) (2)
  Jinbo Fan (3) (4)
  Keming Gao (4)
  Zezhi Li (1)
  Zhenghui Yi (1)
  Lingxiao Wang (1)
  Jia Huang (1)
  Chengmei Yuan (1)
  Wu Hong (1)
  Shunying Yu (5)
  Yiru Fang (1)
  
  1. Department of Psychiatry, Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, 600 South Wan Ping Road, Shanghai, 200030, People’s Republic of China
  2. Department of Psychiatry, Hongkou District Mental Health Center of Shanghai, 159 Tong Xin Road, Shanghai, 200083, People’s Republic of China
  3. Department of Epidemiology and Biostatistics, Case Western Reserve University School of Medicine, Cleveland, OH, USA
  4. Department of Psychiatry, Mood and Anxiety Clinic in the Mood Disorders Program, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, OH, USA
  5. Department of Genetics, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
  

文摘

There is increasing evidence supporting the relationship between bipolar disorder (BP) and neurotrophin. The present study investigated the relationship between neurotrophic tyrosine kinase receptor type 2 (NTRK2) gene polymorphisms and bipolar I disorder (BP I) susceptibility and treatment response to mood stabilizers (lithium or valproate). Two-hundred eighty-four patients who met the DSM-IV criteria for BP I and 295 matched healthy controls were enrolled into this study. TaqMan? SNP genotyping assays were applied to genotype three NTRK2 gene polymorphisms (rs2769605, rs1565445, rs1387923). Our study showed a significant allelic association between NTRK2 gene polymorphism rs2769605 and treatment response to mood stabilizers in BP I patients (t-??2.53, P--.01). However, no significant association between NTRK2 gene polymorphisms and BP I susceptibility was observed after correcting for multiple comparisons. The results suggest that the NTRK2 gene polymorphism likely plays an essential role in treatment response to mood stabilizers in Han Chinese BP I patients.