Blocking heme oxygenase-1 by zinc protoporphyrin reduces tumor hypoxia-mediated VEGF release and inhibits tumor angiogenesis as a potential therapeutic agent against colorectal cancer

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• 作者：Chun-Chia Cheng ; Siao-Syun Guan ; Hao-Jhih Yang…
• 关键词：Angiogenesis ; Heme oxygenase ; 1 ; Tumor hypoxia ; Vascular endothelial growth factor ; Zinc protoporphyrin
• 刊名：Journal of Biomedical Science
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：23
• 期：1
• 全文大小：2,760 KB
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• 作者单位：Chun-Chia Cheng (1) (2)
  Siao-Syun Guan (1)
  Hao-Jhih Yang (1)
  Chun-Chao Chang (3) (4)
  Tsai-Yueh Luo (1)
  Jungshan Chang (5)
  Ai-Sheng Ho (6) (7)
  
  1. Institute of Nuclear Energy Research, Atomic Energy Council, Taoyuan, Taiwan
  2. Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan
  3. Division of Gastroenterology and Hepatology, Department of Internal Medicine, Taipei Medical University Hospital, Taipei, Taiwan
  4. Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
  5. Graduate Institute of Medical Sciences, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan
  6. Division of Gastroenterology, Cheng Hsin General Hospital, Taipei, Taiwan
  7. Nursing Department, Kang-Ning University, Taipei, Taiwan
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Biomedicine
  
• 出版者：Springer Netherlands
• ISSN：1423-0127

文摘

Background Hypoxia in tumor niche is one of important factors to start regeneration of blood vessels, leading to increase survival, proliferation, and invasion in cancer cells. Under hypoxia microenvironment, furthermore, steadily increased hypoxia-inducible factor-1α (HIF-1α) is observed, and can increase vascular endothelial growth factor (VEGF) expression and promote angiogenesis. Zinc protoporphyrin (ZnPP), a heme oxygenase-1 (HO-1) inhibitor, is potential to inhibit tumor proliferation and progression. However, the mechanism of ZnPP in inhibition of tumor is not completely clear. We hypothesize that ZnPP may modulate HIF-1α through inhibiting HO-1, and then inhibit angiogenesis and tumor progression. This study aimed to dissect the mechanism of ZnPP in tumor suppression.