Nephrotoxicity assessments of benzo(a)pyrene during zebrafish embryogenesis

详细信息    查看全文

• 作者：Kang-Chieh Lo (1)
  Chiao-Yin Sun (2)
  Yu-Ju Ding (1)
  Jen-Ning Tsai (3)
  Kai-Ping Chang (4)
  Yi-En Wen (4)
  Wan-Ling Chang (4)
  Shin C. Chang (5)
  Ming-Fu Chang (6)
  Yun-Hsin Wang (7)
  Yau-Hung Chen (1)
  
• 关键词：Benzo(a)pyrene ; Embryogenesis ; Kidney ; Nephrotoxicity ; Zebrafish
• 刊名：Research on Chemical Intermediates
• 出版年：2014
• 出版时间：July 2014
• 年：2014
• 卷：40
• 期：6
• 页码：2177-2185
• 全文大小：
• 参考文献：1. B.K. Larsson, G.P. Sahlberg, A.T. Eriksson, L.A. Busk, J. Agric. Food Chem. 31, 867 (1983) CrossRef
  2. K. Maskaoui, J.L. Zhou, H.S. Hong, Environ. Pollut. 118, 109 (2002) CrossRef
  3. Y. Tian, T.L. Zheng, X.H. Wang, Oceanol. Limnol. Sin. 35, 15 (2004)
  4. A. Weston, D.H. Manchester, M.C. Poirier, J.S. Choi, G.E. Trivers, D.L. Mann, Chem. Res. Toxicol. 2, 104 (1989) CrossRef
  5. M.F. Denissenko, A. Pao, M. Tang, G.P. Pfeifer, Science 274, 430 (1996) CrossRef
  6. E.L. Jamin, A. Riu, T. Douki, L. Debrauwer, J.P. Cravedi, D. Zalko, M. Audebert, PLoS ONE 8, e58591 (2013) CrossRef
  7. S. Labib, C.H. Guo, A. Williams, C.L. Yauk, P.A. White, S. Halappanavar, Toxicol. Appl. Pharmacol. 273, 269 (2013) CrossRef
  8. D.E. Bassi, A.J. Klein-Szanto, Curr. Protoc. Pharmacol. Chapter 14: Unit 14.2 (2007)
  9. F. Kassie, L.B. Anderson, L. Higgins, Y. Pan, I. Matise, M. Negia, P. Upadhyaya, M. Wang, S.S. Hecht, Carcinogenesis 29, 610 (2008) CrossRef
  10. Q. Xia, H.M. Chiang, J.J. Yin, S. Chen, L. Cai, H. Yu, P. Fu. Toxicol. Ind. Health. (in press)
  11. T. Duarte-Salles, M.A. Mendez, H.M. Meltzer, J. Alexander, M. Haugen, Environ. Int. 60, 217 (2013) CrossRef
  12. C. Chen, Y. Tang, X. Jiang, Y. Qi, S. Cheng, C. Qiu, B. Peng, B. Tu, Toxicol. Sci. 125, 248 (2012) CrossRef
  13. B.J. Bugiak, L.P. Webe, Aquat. Toxicol. 99, 423 (2010) CrossRef
  14. J.L. Mu, X.H. Wang, F. Jin, J.Y. Wang, H.S. Hong, Mar. Pollut. Bull. 64, 1445 (2012) CrossRef
  15. X. Ren, F. Lu, Y. Cui, X. Wang, C. Bai, J. Chen, C. Huang, D. Yang, Hum. Exp. Toxicol. 31, 1161 (2012) CrossRef
  16. B.J. Bugiak, L.P. Weber, Aquat. Toxicol. 95, 299 (2009) CrossRef
  17. L. Huang, C. Wang, Y. Zhang, J. Li, Y. Zhong, Y. Zhou, Y. Chen, Chemosphere 87, 369 (2012) CrossRef
  18. I. Drummond, Trends Cell Biol. 13, 357 (2003) CrossRef
  19. B. Perner, C. Englert, F. Bollig, Dev. Biol. 309, 87 (2007) CrossRef
  20. C. Kimmel, W.W. Ballard, S.R. Kimmel, B. Ullmann, T.F. Schilling, Dev. Dyn. 203, 253 (1995) CrossRef
  21. H.J. Tsay, Y.H. Wang, W.L. Chen, M.Y. Huang, Y.H. Chen, Neurotoxicol. Teratol. 29, 562 (2007) CrossRef
  22. M.D. Lin, H.T. Lee, S.C. Wang, H.R. Lee, H.L. Hsien, K.W. Cheng, Y.D. Chang, M.L. Huang, J.K. Yu, Y.H. Chen, BMC Dev. Biol. 13, 18 (2013) CrossRef
  23. Y.J. Ding, X.G. Chen, Y.H. Chen, Russ. J. Dev. Biol. 44, 307 (2013) CrossRef
  24. G.H. Lee, M.Y. Chang, C.H. Hsu, Y.H. Chen, Cell. Mol. Life Sci. 68, 4065 (2011) CrossRef
  25. Y.J. Ding, Y.H. Chen, Toxicol. Appl. Pharmacol. 261, 59 (2012) CrossRef
  26. J.L. Hoffmann, J.T. Oris, Aquat. Toxicol. 78, 332 (2006) CrossRef
  27. X. Fang, C. Thornton, B.E. Scheffler, K.L. Willett, Environ. Toxicol. Pharmacol. 36, 40 (2013) CrossRef
  
• 作者单位：Kang-Chieh Lo (1)
  Chiao-Yin Sun (2)
  Yu-Ju Ding (1)
  Jen-Ning Tsai (3)
  Kai-Ping Chang (4)
  Yi-En Wen (4)
  Wan-Ling Chang (4)
  Shin C. Chang (5)
  Ming-Fu Chang (6)
  Yun-Hsin Wang (7)
  Yau-Hung Chen (1)
  
  1. Department of Chemistry, Tamkang University, No. 151 Ying-chuan Road, Tamsui District, New Taipei City 251, Taiwan
  2. Department of Nephrology, Chang Gung Memorial Hospital, Keelung, Taiwan
  3. School of Medical Laboratory and Biotechnology, Chung Shan Medical University, Taichung, Taiwan
  4. Taipei Fuhsing Private School, Taipei, Taiwan
  5. Institute of Microbiology, National Taiwan University College of Medicine, Taipei, Taiwan
  6. Institute of Biochemistry and Molecular Biology, National Taiwan University College of Medicine, Taipei, Taiwan
  7. Division of Basic Research, Koo Foundation Sun Yat-Sen Cancer Center, Taipei, Taiwan
  
• ISSN：1568-5675

文摘

Benzo(a)pyrene is a chemical produced during the process of making fried, roasted, and smoked foods. It remains unclear whether benzo(a)pyrene affects the early development of human organs. In this study, we used the transgenic zebrafish line Tg(wt1b:GFP) as a model to assess benzo(a)pyrene-induced kidney malformation. By soaking zebrafish embryos in benzo(a)pyrene at various doses (2, 20, and 200?ppb), only a minor effect on the survival rate was detected (0?ppb: 97.8?±?1.9?%; 2-00?ppb: 89.1?±?5.8-1.5?±?8.3?%). However, benzo(a)pyrene significantly affected the development of the kidney (malformation rates ranges from 50.0?±?3.5 to 77.4?±?5.3?%). Various abnormalities, such as unusual curving of pronephric tubes, swollen glomerulus, and incomplete development of pronephric ducts, were observed. This study provides a rapid and effective protocol for the evaluation of the notable effects of benzo(a)pyrene on embryonic kidney development.