Clinical characteristics of children with positive anti-SSA/SSB antibodies

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• 作者：Pei-Hsuan Chen (1)
  Yao-Hsu Yang (1)
  Yu-Tsan Lin (1)
  Jyh-Hong Lee (1)
  Li-Chieh Wang (1)
  Hsin-Hui Yu (1)
  Bor-Luen Chiang (1) (2)
  
• 关键词：Anti ; SSA antibody ; Anti ; SSB antibody ; Pediatric Sj?gren’s syndrome
• 刊名：Rheumatology International
• 出版年：2014
• 出版时间：August 2014
• 年：2014
• 卷：34
• 期：8
• 页码：1123-1127
• 全文大小：154 KB
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• 作者单位：Pei-Hsuan Chen (1)
  Yao-Hsu Yang (1)
  Yu-Tsan Lin (1)
  Jyh-Hong Lee (1)
  Li-Chieh Wang (1)
  Hsin-Hui Yu (1)
  Bor-Luen Chiang (1) (2)
  
  1. Department of Pediatrics, National Taiwan University Hospital, College of Medicine, National Taiwan University, Taipei, Taiwan
  2. Graduate and Institute of Immunology, National Taiwan University, No. 7 Chung-Shan South Road, Taipei, 100, Taiwan
  
• ISSN：1437-160X

文摘

This study aimed to characterize the manifestations of clinical symptoms and signs, primary rheumatic diseases, and other autoantibodies in pediatric patients with positive anti-SSA and/or anti-SSB antibodies. Subjects under age 18 with positive anti-SSA and/or anti-SSB antibodies were screened and enrolled in a tertiary hospital in Taiwan. Data were collected via medical records, including age, gender, onset of the primary rheumatic disease, clinical symptoms and signs, and the medication used. Schirmer test for Sj?gren’s syndrome (SS) screening was performed in all enrolled patients. Among twenty enrolled subjects, seventeen of them had systemic lupus erythematosus; four of them were diagnosed as SS with positive Schirmer test. In addition to antinuclear antibodies and anti-DNA antibodies, other common autoantibodies were anti-RNP antibodies (50?%) and anti-Sm antibodies (30?%). The most common symptoms were arthritis (60?%) followed by malar rash (40?%). In conclusion, we observed that a low proportion of childhood SS (4/20) exists in our patients with positive SSA and/or anti-SSB antibodies. It is suggested that clinicians should focus more on the clinical symptoms in these patients, rather than undertaking invasive diagnostic interventions to rule out Sj?gren’s syndrome.