A Decision Tree Based Classifier to Analyze Human Ovarian Cancer cDNA Microarray Datasets

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• 作者：Meng-Hsiun Tsai ; Hsin-Chieh Wang ; Guan-Wei Lee ; Yi-Chen Lin…
• 关键词：Ovarian cancer ; Decision tree ; C&RT ; CHAID ; Ingenuity Pathway Analysis
• 刊名：Journal of Medical Systems
• 出版年：2016
• 出版时间：January 2016
• 年：2016
• 卷：40
• 期：1
• 全文大小：1,135 KB
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• 作者单位：Meng-Hsiun Tsai (1) (2)
  Hsin-Chieh Wang (1)
  Guan-Wei Lee (1)
  Yi-Chen Lin (1)
  Sheng-Hsiung Chiu (3)
  
  1. Department of Management Information System, National Chung Hsing University, No.250, Kuo Kuang Rd., Taichung City, 402, Taiwan
  2. Institute of Genomics and Bioinformatics, National Chung Hsing University, No.250, Kuo Kuang Rd., Taichung City, 402, Taiwan
  3. Troilus Bio-Technology Co. Ltd., Taiwan, Republic of China
  
• 刊物类别：Mathematics and Statistics
• 刊物主题：Statistics
  Statistics for Life Sciences, Medicine and Health Sciences
  Health Informatics and Administration
  
• 出版者：Springer Netherlands
• ISSN：1573-689X

文摘

Ovarian cancer is the deadliest gynaecological disease because of the high mortality rate and there is no any symptom in cancer early stage. It was often the terminal cancer period when patients were diagnosed with ovarian cancer and thus delays a good opportunity of treatment. The current common method for detecting ovarian cancer is blood testing for analyzing the tumor marker CA-125 of serum. However, specificity and sensitivity of CA-125 are insufficient for early detection. Therefore, it has become an urgent issue to look for an efficient method which precisely detects the tumor markers for ovarian cancer. This study aims to find the target genes of ovarian cancer by different algorithms of information science. Feature selection and decision tree were applied to analyze 9600 ovarian cancer-related genes. After screening the target genes, candidate genes will be analyzed by Ingenuity Pathway Analysis (IPA) software to create a genetic pathway model and to understand the interactive relationship in the different pathological stages of ovarian cancer. Finally, this research found 9 oncogenes associated with ovarian cancer and some genes had not been discovered in previous studies. This system will assist medical staffs in diagnosis and treatment at cancer early stage and improve the patient鈥檚 survival. Keywords Ovarian cancer Decision tree C&RT CHAID Ingenuity Pathway Analysis