α-Carboline derivative TJY-16 inhibits tumor growth by inducing G2/M cell cycle arrest in glioma cells

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• 作者：Hsiao-Chieh Huang ; Wei-Ting Liu ; Kuo-Su Hua ; Hui-Chi Hung…
• 关键词：Glioblastoma multiforme ; Carboline derivatives ; Cell cycle arrest ; Apoptosis ; G2/M arrest
• 刊名：Journal of Biomedical Science
• 出版年：2016
• 出版时间：December 2016
• 年：2016
• 卷：23
• 期：1
• 全文大小：3,026 KB
• 参考文献：1.Schwartzbaum JA, Fisher JL, Aldape KD, Wrensch M. Epidemiology and molecular pathology of glioma. Nat Clin Pract Neurol. 2006;2:494–503.PubMed CrossRef
  2.Soderberg-Naucler C, Rahbar A, Stragliotto G. Survival in patients with glioblastoma receiving valganciclovir. N Engl J Med. 2013;369:985–6.PubMed CrossRef
  3.Wen PY, Kesari S. Malignant gliomas in adults. N Engl J Med. 2008;359:492–507.PubMed CrossRef
  4.Ostrom QT, Gittleman H, Farah P, Ondracek A, Chen Y, Wolinsky Y, et al. CBTRUS statistical report: Primary brain and central nervous system tumors diagnosed in the United States in 2006–2010. Neuro Oncol. 2013;15 Suppl 2:ii1–56.PubMed PubMedCentral CrossRef
  5.Stevens MF, Hickman JA, Langdon SP, Chubb D, Vickers L, Stone R, et al. Antitumor activity and pharmacokinetics in mice of 8-carbamoyl-3-methyl-imidazo[5,1-d]-1,2,3,5-tetrazin-4(3H)-one (CCRG 81045; M & B 39831), a novel drug with potential as an alternative to dacarbazine. Cancer Res. 1987;47:5846–52.PubMed
  6.Kioi M, Vogel H, Schultz G, Hoffman RM, Harsh GR, Brown JM. Inhibition of vasculogenesis, but not angiogenesis, prevents the recurrence of glioblastoma after irradiation in mice. J Clin Invest. 2010;120:694–705.PubMed PubMedCentral CrossRef
  7.Hou LC, Veeravagu A, Hsu AR, Tse VC. Recurrent glioblastoma multiforme: a review of natural history and management options. Neurosurg Focus. 2006;20:E3.CrossRef
  8.Chauhan SS, Singh AK, Meena S, Lohani M, Singh A, Arya RK, et al. Synthesis of novel beta-carboline based chalcones with high cytotoxic activity against breast cancer cells. Bioorg Med Chem Lett. 2014;24:2820–4.PubMed CrossRef
  9.Daoud A, Song J, Xiao F, Shang J. B-9-3, a novel beta-carboline derivative exhibits anti-cancer activity via induction of apoptosis and inhibition of cell migration in vitro. Eur J Pharmacol. 2014;724:219–30.PubMed CrossRef
  10.Abe A, Yamada H, Moriya S, Miyazawa K. The beta-carboline alkaloid harmol induces cell death via autophagy but not apoptosis in human non-small cell lung cancer A549 cells. Biol Pharm Bull. 2011;34:1264–72.PubMed CrossRef
  11.Ashok P, Ganguly S, Murugesan S. Review on in-vitro anti-malarial activity of natural beta-carboline alkaloids. Mini Rev Med Chem. 2013;13:1778–91.PubMed CrossRef
  12.Drucker G, Raikoff K, Neafsey EJ, Collins MA. Dopamine uptake inhibitory capacities of beta-carboline and 3,4-dihydro-beta-carboline analogs of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) oxidation products. Brain Res. 1990;509:125–33.PubMed CrossRef
  13.Fiszer-Maliszewska L, Mordarski M. Antineoplastic activity of azacarbazoles. II. Effect of alpha-carboline and its derivatives on transplantable animal neoplasms. Arch Immunol Ther Exp (Warsz). 1987;35:221–4.
  14.Helbecque N, Moquin C, Bernier JL, Morel E, Guyot M, Henichart JP. Grossularine-1 and grossularine-2, alpha carbolines from Dendrodoa grossularia, as possible intercalative agents. Cancer Biochem Biophys. 1987;9:271–9.PubMed
  15.Oda T, Lee JS, Sato Y, Kabe Y, Sakamoto S, Handa H, et al. Inhibitory effect of N,N-didesmethylgrossularine-1 on inflammatory cytokine production in lipopolysaccharide-stimulated RAW 264.7 cells. Mar Drugs. 2009;7:589–99.PubMed PubMedCentral CrossRef
  16.Tsai JY, Hung CM, Bai ST, Huang CH, Chen WC, Chung JG, et al. Induction of apoptosis by HAC-Y6, a novel microtubule inhibitor, through activation of the death receptor 4 signaling pathway in human hepatocellular carcinoma cells. Oncol Rep. 2010;24:1169–78.PubMed
  17.DiPaola RS. To arrest or not to G(2)-M Cell-cycle arrest : commentary re: A. K. Tyagi et al., Silibinin strongly synergizes human prostate carcinoma DU145 cells to doxorubicin-induced growth inhibition, G(2)-M arrest, and apoptosis. Clin. cancer res., 8: 3512–3519, 2002. Clinical cancer research. 2002;8:3311–4.PubMed
  18.Senderowicz AM, Sausville EA. Preclinical and clinical development of cyclin-dependent kinase modulators. J Natl Cancer Inst. 2000;92:376–87.PubMed CrossRef
  19.Maddika S, Ande SR, Panigrahi S, Paranjothy T, Weglarczyk K, Zuse A, et al. Cell survival, cell death and cell cycle pathways are interconnected: implications for cancer therapy. Drug Resist Updat. 2007;10:13–29.PubMed CrossRef
  20.Zhou YH, Wu X, Tan F, Shi YX, Glass T, Liu TJ, et al. PAX6 suppresses growth of human glioblastoma cells. J Neurooncol. 2005;71:223–9.PubMed CrossRef
  21.Strober W. Trypan blue exclusion test of cell viability. Current protocols in immunology / edited by John E Coligan [et al.]. 2001;Appendix 3:Appendix 3B.
  22.Riedl SJ, Shi Y. Molecular mechanisms of caspase regulation during apoptosis. Nat Rev Mol Cell Biol. 2004;5:897–907.PubMed CrossRef
  23.Esposti MD. The roles of Bid. Apoptosis. 2002;7:433–40.PubMed CrossRef
  24.Tsai JY, Lin YC, Hsu MH, Kuo SC, Huang LJ. Synthesis and cytotoxicity of 1,6,8,9-substituted alpha-carboline derivatives. Kaohsiung J Med Sci. 2010;26:593–602.PubMed CrossRef
  25.Vitale I, Galluzzi L, Castedo M, Kroemer G. Mitotic catastrophe: a mechanism for avoiding genomic instability. Nat Rev Mol Cell Biol. 2011;12:385–92.PubMed CrossRef
  26.Castedo M, Perfettini JL, Roumier T, Andreau K, Medema R, Kroemer G. Cell death by mitotic catastrophe: a molecular definition. Oncogene. 2004;23:2825–37.PubMed CrossRef
  27.Sliwinska MA, Mosieniak G, Wolanin K, Babik A, Piwocka K, Magalska A, et al. Induction of senescence with doxorubicin leads to increased genomic instability of HCT116 cells. Mech Ageing Dev. 2009;130:24–32.PubMed CrossRef
  28.Park WH, Seol JG, Kim ES, Hyun JM, Jung CW, Lee CC, et al. Arsenic trioxide-mediated growth inhibition in MC/CAR myeloma cells via cell cycle arrest in association with induction of cyclin-dependent kinase inhibitor, p21, and apoptosis. Cancer Res. 2000;60:3065–71.PubMed
  29.Wang D, Lippard SJ. Cellular processing of platinum anticancer drugs. Nat Rev Drug Discov. 2005;4:307–20.PubMed CrossRef
  30.Elmore S. Apoptosis: a review of programmed cell death. Toxicol Pathol. 2007;35:495–516.PubMed PubMedCentral CrossRef
  31.Li H, Zhu H, Xu CJ, Yuan J. Cleavage of BID by caspase 8 mediates the mitochondrial damage in the Fas pathway of apoptosis. Cell. 1998;94:491–501.PubMed CrossRef
  32.Lin YC, Tsai JY, Yang JS, Lee YH, Hamel E, Lee KH, et al. The novel synthetic compound 6-acetyl-9-(3,4,5-trimethoxybenzyl)-9H-pyrido[2,3-b]indole induces mitotic arrest and apoptosis in human COLO 205 cells. International J Oncology. 2015;43:1596–606.
  33.Plowman J, Waud WR, Koutsoukos AD, Rubinstein LV, Moore TD, Grever MR. Preclinical Antitumor Activity of Temozolomide in Mice: Efficacy against Human Brain Tumor Xenografts and Synergism with 1,3-Bis(2-chloroethyl)-1-nitrosourea. Cancer Res. 1994;54:3793–9.PubMed
  
• 作者单位：Hsiao-Chieh Huang (1)
  Wei-Ting Liu (1)
  Kuo-Su Hua (1)
  Hui-Chi Hung (1)
  Jui-Ying Tsai (2)
  Sheng-Chu Kuo (2)
  Li-Jiau Huang (2)
  Po-Wu Gean (1)
  
  1. Department of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, Taiwan
  2. Graduate Institute of Pharmaceutical Chemistry, China Medical University, Taichung, Taiwan
  
• 刊物类别：Biomedical and Life Sciences
• 刊物主题：Biomedicine
  Biomedicine
  
• 出版者：Springer Netherlands
• ISSN：1423-0127

文摘

Background Glioblastoma multiforme (GBM) is the most lethal primary brain tumors which remains difficult to cure despite advances in surgery, radiotherapy and chemotherapy. Therefore, the development of new drug is urgently needed. α-carboline derivatives were usually isolated from marine animals such as Britannia marine tunicate Dendrodoa grossularia and Indonesian ascidian Polycarpa aurata. In this study, we have synthesized several α-carboline compounds and examined their anti-glioma activities.