Genetic variants of glutamate receptor gene family in Taiwanese Kawasaki disease children with coronary artery aneurysms

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• 作者：Ying-Ju Lin (1) (2)
  Jeng-Sheng Chang (3)
  Xiang Liu (4)
  Hsinyi Tsang (4)
  Ting-Hsu Lin (1)
  Chiu-Chu Liao (1)
  Shao-Mei Huang (1)
  Wen-Kuei Chien (5) (6)
  Jin-Hua Chen (5) (6)
  Jer-Yuarn Wu (2) (7)
  Chien-Hsiun Chen (2) (7)
  Li-Ching Chang (7)
  Cheng-Wen Lin (8)
  Tsung-Jung Ho (10) (2) (9)
  Fuu-Jen Tsai (1) (11) (2)
  
  1. Department of Medical Research ; China Medical University Hospital ; Taichung ; Taiwan
  2. School of Chinese Medicine ; China Medical University ; Taichung ; Taiwan
  3. Department of Pediatrics ; China Medical University Hospital ; Taichung ; Taiwan
  4. National Institute of Allergy and Infectious Diseases ; National Institutes of Health ; Bethesda ; Maryland ; USA
  5. Biostatistics Center ; China Medical University ; Taichung ; Taiwan
  6. Biostatistics Center and School of Public Health ; Taipei Medical University ; Taipei ; Taiwan
  7. Institute of Biomedical Sciences ; Academia Sinica ; Taipei ; Taiwan
  8. Department of Medical Laboratory Science and Biotechnology ; China Medical University ; Taichung ; Taiwan
  10. Division of Chinese Medicine ; Tainan Municipal An-Nan Hospital -China Medical University ; Tainan ; Taiwan
  9. Division of Chinese Medicine ; China Medical University Beigang Hospital ; Yunlin County ; Taiwan
  11. Asia University ; Taichung ; Taiwan
  
• 关键词：KD ; GRIK1 ; Single nucleotide polymorphism ; CAA
• 刊名：Cell & Bioscience
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：4
• 期：1
• 全文大小：529 KB
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• 刊物主题：Cell Biology; Microbiology;
• 出版者：BioMed Central
• ISSN：2045-3701

文摘

Background Patients with Kawasaki disease (KD), a pediatric systemic vasculitis, may develop coronary artery aneurysm (CAA) as a complication. To investigate the role of glutamate receptors in KD and its CAA development, we performed genetic association studies. Methods and results We examined the whole family of glutamate receptors by genetic association studies in a Taiwanese cohort of 262 KD patients. We identified glutamate receptor ionotropic, kainate 1 (GRIK1) as a novel susceptibility locus associated with CAA formation in KD. Statistically significant differences were noted for factors like fever duration, 1st Intravenous immunoglobulin (IVIG) used time (number of days after the first day of fever) and the GRIK1 (rs466013, rs425507, and rs38700) genetic variants. This significant association persisted even after using multivariate regression analysis (Full model: for rs466013: odds ratio =2.12; 95% CI =1.22-3.65; for rs425507: odds ratio =2.16; 95% CI =1.26-3.76; for rs388700: odds ratio =2.16; 95% CI =1.26-3.76). Conclusions We demonstrated that GRIK1 polymorphisms are associated CAA formation in KD, even when adjusted for fever duration and IVIG used time, and may also serve as a genetic marker for the CAA formation in KD.