Plasma growth arrest-specific protein 6 levels in premenopausal and postmenopausal women: the role of endogenous estrogen

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• 作者：Yi-Jen Hung (1)
  Chien-Hsing Lee (1)
  Yi-Shing Shieh (2) (3)
  Fone-Ching Hsiao (1)
  Fu-Huang Lin (4)
  Chang-Hsun Hsieh (1)
  
• 关键词：Gas6 ; Estradiol ; Premenopausal ; Postmenopausal women ; Sex hormone ; binding globulin ; Free estrogen index
• 刊名：Endocrine
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：47
• 期：3
• 页码：923-929
• 全文大小：409 KB
• 参考文献：1. G. Manfioletti, C. Brancolini, G. Avanzi, C. Schneider, The protein encoded by a growth arrest-specific gene (gas6) is a new member of the vitamin K-dependent proteins related to protein S, a negative coregulator in the blood coagulation cascade. Mol. Cell. Biol. 13, 4976-985 (1993)
  2. C. Ekman, J. Stenhoff, B. Dahlback, Gas6 is complexed to the soluble tyrosine kinase receptor Axl in human blood. J. Thromb. Haemost. 8, 838-44 (2010) CrossRef
  3. I. Balogh, S. Hafizi, J. Stenhoff, K. Hansson, B. Dahlback, Analysis of Gas6 in human platelets and plasma. Arterioscler. Thromb. Vasc. Biol. 25, 1280-286 (2005) CrossRef
  4. M. Yanagita, Y. Ishimoto, H. Arai, K. Nagai, T. Ito, T. Nakano, D.J. Salant, A. Fukatsu, T. Doi, T. Kita, Essential role of Gas6 for glomerular injury in nephrotoxic nephritis. J. Clin. Investig. 110, 239-46 (2002) CrossRef
  5. E. Lutgens, M. Tjwa, P. Garcia de Frutos, E. Wijnands, L. Beckers, B. Dahlback, M.J. Daemen, P. Carmeliet, L. Moons, Genetic loss of Gas6 induces plaque stability in experimental atherosclerosis. J. Pathol. 216, 55-3 (2008) CrossRef
  6. E. Maquoi, G. Voros, P. Carmeliet, D. Collen, H.R. Lijnen, Role of Gas-6 in adipogenesis and nutritionally induced adipose tissue development in mice. Arterioscler. Thromb. Vasc. Biol. 25, 1002-007 (2005) CrossRef
  7. M. Tjwa, L. Bellido-Martin, Y. Lin, E. Lutgens, S. Plaisance, F. Bono, N. Delesque-Touchard, C. Herve, R. Moura, A.D. Billiau, C. Aparicio, M. Levi, M. Daemen, M. Dewerchin, F. Lupu, J. Arnout, J.M. Herbert, M. Waer, P. Garcia de Frutos, B. Dahlback, P. Carmeliet, M.F. Hoylaerts, L. Moons, Gas6 promotes inflammation by enhancing interactions between endothelial cells, platelets, and leukocytes. Blood 111, 4096-105 (2008) CrossRef
  8. P.J. Godowski, M.R. Mark, J. Chen, M.D. Sadick, H. Raab, R.G. Hammonds, Reevaluation of the roles of protein S and Gas6 as ligands for the receptor tyrosine kinase Rse/Tyro 3. Cell 82, 355-58 (1995) CrossRef
  9. S. Goruppi, E. Ruaro, C. Schneider, Gas6, the ligand of Axl tyrosine kinase receptor, has mitogenic and survival activities for serum starved NIH3T3 fibroblasts. Oncogene 12, 471-80 (1996)
  10. E.C. Shugart, A.S. Levenson, C.M. Constance, R.M. Umek, Differential expression of gas and gadd genes at distinct growth arrest points during adipocyte development. Cell Growth Differ. 6, 1541-547 (1995)
  11. C. Ekman, A. Gottsater, B. Lindblad, B. Dahlback, Plasma concentrations of Gas6 and soluble Axl correlate with disease and predict mortality in patients with critical limb ischemia. Clin. Biochem. 43, 873-76 (2010) CrossRef
  12. C. Ekman, A. Linder, P. Akesson, B. Dahlback, Plasma concentrations of Gas6 (growth arrest specific protein 6) and its soluble tyrosine kinase receptor sAxl in sepsis and systemic inflammatory response syndromes. Crit. Care (London, England) 14, R158 (2010) CrossRef
  13. S. Gibot, F. Massin, A. Cravoisy, R. Dupays, D. Barraud, L. Nace, P.E. Bollaert, Growth arrest-specific protein 6 plasma concentrations during septic shock. Crit. Care (London, England) 11, R8 (2007) CrossRef
  14. L. Jiang, C.Y. Liu, Q.F. Yang, P. Wang, W. Zhang, Plasma level of growth arrest-specific 6 (GAS6) protein and genetic variations in the GAS6 gene in pati
• 作者单位：Yi-Jen Hung (1)
  Chien-Hsing Lee (1)
  Yi-Shing Shieh (2) (3)
  Fone-Ching Hsiao (1)
  Fu-Huang Lin (4)
  Chang-Hsun Hsieh (1)
  
  1. Division of Endocrinology and Metabolism, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, No 325, Sec 2, Cheng-Gong Rd, Nei-Hu, Taipei, Taiwan
  2. School of Dentistry, National Defense Medical Center, Taipei, Taiwan
  3. Department of Oral Diagnosis and Pathology, Tri-Service General Hospital, Taipei, Taiwan
  4. School of Public Health, National Defense Medical Center, Taipei, Taiwan
  
• ISSN：1559-0100

文摘

Growth arrest-specific 6 (Gas6) is a vitamin K-dependent protein that interacts with receptor tyrosine kinases of the Tyro-3, AXL, Mer (TAM) family. The Gas6/TAM system contributes to the regulation of cell survival and proliferation, cell adhesion and migration, and inflammatory cytokines release. Plasma Gas6 plays an important role in the inflammatory process, and is involved in diverse human diseases. Few studies have investigated gender-specific variations in plasma Gas6 concentration. Hence, the aim of this study was to determine whether plasma Gas6 levels are associated with sex hormones in premenopausal and postmenopausal women. A total of 103 premenopausal and 135 postmenopausal women were recruited. Plasma Gas6 concentration, estradiol (E2), and sex hormone-binding globulin were assayed. The free estrogen index (FEI) was calculated. The results showed significantly lower Gas6 levels in the postmenopausal compared to the premenopausal women (P?r?=?0.359, P?r?=?0.261, P?=?0.002, respectively). Gas6 levels were also correlated with FEI in the pre- and postmenopausal women (r?=?0.234, P?=?0.017 and r?=?0.188, P?=?0.029, respectively). After adjusting for confounders, the correlations still remained significant. In multiple stepwise regression analysis, only E2 in premenopausal and both age and E2 in postmenopausal women were independently correlated with the plasma Gas6 levels (all P?