Migraine and Reward System—Or Is It Aversive?
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- 作者：Catherine M. Cahill (1)
Christopher Cook (3)
Sarah Pickens (2) - 关键词：Pain ; Aversion ; Reward ; Negative affect ; Dopamine ; Ventral tegmental area ; Nucleus accumbens
- 刊名：Current Pain and Headache Reports
- 出版年：2014
- 出版时间：May 2014
- 年：2014
- 卷：18
- 期：5
- 全文大小：418 KB
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Christopher Cook (3)
Sarah Pickens (2)
1. Department of Anesthesiology & Perioperative Care, 837 Health Sciences Rd, 2117 Gillespie Neuroscience Research Facility, Irvine, CA, 92697, USA
3. Department of Pharmacology, University of California, Irvine, 2226, Gillespie Neuroscience Research Facility, Irvine, CA, 92617, USA
2. Department of Anesthesiology & Perioperative Care, University of California, Irvine, 2226, Gillespie Neuroscience Research Facility, Irvine, CA, 92617, USA - ISSN：1534-3081
文摘
Migraine is a debilitating neurological disorder with grave consequences for both the individual and society. This review will focus on recent literature investigating how brain structures implicated in reward and aversion contribute to the genesis of migraine pain. There exist many overlapping and interacting brain regions within pain and reward circuitry that contribute to negative affect and subjective experience of pain. The emotional component of pain has been argued to be a greater metric of quality of life than its sensory component, and thus understanding the processes that influence this pain characteristic is essential to developing novel treatment strategies for mitigating migraine pain. We emphasize and provide evidence that abnormalities within the mesolimbic cortical reward pathways contribute to migraine pain and that there are structural and functional neuroplasticity within the overlapping brain regions common to both pain and reward.