Recent knowledge concerning mammalian sperm chromatin organization and its potential weaknesses when facing oxidative challenge

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• 作者：Anais Noblanc ; Ayhan Kocer ; Jo?l R Drevet
• 关键词：Spermatozoa ; Protamines ; Histones ; Sperm DNA integrity ; DNA oxidative damage ; Spermatozo?des ; Protamines ; Histones ; Intégrité du noyau spermatique ; Dommage oxydant à l’ADN
• 刊名：Basic and Clinical Andrology
• 出版年：2014
• 出版时间：December 2014
• 年：2014
• 卷：24
• 期：1
• 全文大小：1,085 KB
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• 刊物主题：Urology/Andrology; Reproductive Medicine; Endocrinology; Surgery; Gynecology;
• 出版者：BioMed Central
• ISSN：2051-4190

文摘

Spermatozoa are the smallest and most cyto-differentiated mammalian cells. From a somatic cell-like appearance at the beginning of spermatogenesis, the male germ cell goes through a highly sophisticated process to reach its final organization entirely devoted to its mission which is to deliver the paternal genome to the oocyte. In order to fit the paternal DNA into the tiny spermatozoa head, complete chromatin remodeling is necessary. This review essentially focuses on present knowledge of this mammalian sperm nucleus compaction program. Particular attention is given to most recent advances that concern the specific organization of mammalian sperm chromatin and its potential weaknesses. Emphasis is placed on sperm DNA oxidative damage that may have dramatic consequences including infertility, abnormal embryonic development and the risk of transmission to descendants of an altered paternal genome.