Liver transplantation in acute-on-chronic liver failure: lessons learnt from acute liver failure setting

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• 作者：Mettu Srinivas Reddy ; Rajesh Rajalingam ; Mohamed Rela
• 关键词：Acute ; on ; chronic liver failure ; Acute liver failure ; Liver transplantation ; Listing criteria ; Multi organ dysfunction
• 刊名：Hepatology International
• 出版年：2015
• 出版时间：October 2015
• 年：2015
• 卷：9
• 期：4
• 页码：508-513
• 全文大小：354 KB
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• 作者单位：Mettu Srinivas Reddy (1)
  Rajesh Rajalingam (1)
  Mohamed Rela (1)
  
  1. National Foundation for Liver Research, Institute of Liver Disease and Transplantation, Global Health City, Chennai, India
  
• 刊物主题：Hepatology; Colorectal Surgery; Surgery;
• 出版者：Springer India
• ISSN：1936-0541

文摘

Acute-on-chronic liver failure is a clinical entity with high risk of mortality. These patients can have severe liver dysfunction complicated with multiple organ failure. Liver transplantation is the definitive treatment for these patients. Literature regarding management of acute liver failure with special emphasis on liver transplantation was reviewed. Lessons learnt from the management of patients with acute liver failure which could be extrapolated to the management of patients with acute-on-chronic liver failure are discussed. Significant improvement in outcomes of acute liver failure has been reported across the world. Several aspects in transplantation for acute liver failure were found to be relevant to the management of acute-on-chronic liver failure. These include defining criteria to identify patients needing early liver transplantation, prioritizing patients with acute liver failure on the waiting list, defining when to abandon transplantation in acute liver failure, emphasis on graft quality and the need for a multi-disciplinary approach to manage multiple organ dysfunction. Useful lessons can be learnt from the progress made in the management of acute liver failure and these can be extrapolated to the management of patients with acute-on-chronic liver failure. Keywords Acute-on-chronic liver failure Acute liver failure Liver transplantation Listing criteria Multi organ dysfunction