Therapeutic vaccine targeting Epstein-Barr virus latent protein, LMP1, suppresses LMP1-expressing tumor growth and metastasis in vivo
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- 作者：Mei-Chun Lin ; Yong-Chong Lin ; Syue-Ting Chen ; Tai-Horng Young ; Pei-Jen Lou
- 关键词：Epstein ; Barr virus (EBV) ; Latent membrane protein 1 (LMP1) ; Nasopharyngeal carcinoma (NPC) ; DNA vaccine ; Cytotoxic T lymphocyte (CTL)
- 刊名：BMC Cancer
- 出版年：2017
- 出版时间：December 2017
- 年：2017
- 卷：17
- 期：1
- 全文大小：1129KB
- 刊物主题：Cancer Research; Oncology; Surgical Oncology; Health Promotion and Disease Prevention; Biomedicine, general; Medicine/Public Health, general;
- 出版者：BioMed Central
- ISSN：1471-2407
- 卷排序：17
文摘
BackgroundIn endemic area, nasopharyngeal carcinoma (NPC) tumor cells harbor EBV latent infection and expresses viral antigens such as EBNA1, LMP1 and LMP2. In this study, we established a NPC-mimicry animal model and assessed the therapeutic potential of LMP1 vaccine.