Allograft inflammatory factor-1 alleviates liver disease of BALB/c mice infected with Schistosoma japonicum
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- 作者：Qiong-Rong Chen (1) (3)
Fei Guan (2)
Shu-Mei Song (3)
Jian-Kang Jin (3)
Dan-Sheng Lei (4)
Chun-Mei Chen (1)
Jia-Hui Lei (2)
Zheng-Wang Chen (5)
An-Ou Niu (2) - 关键词：Allograft inflammatory factor ; 1 ; Fibrosis ; Liver ; Necrosis ; Schistosomiasis ; Schistosoma japonicum
- 刊名：Parasitology Research
- 出版年：2014
- 出版时间：July 2014
- 年：2014
- 卷：113
- 期：7
- 页码：2629-2639
- 全文大小：
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Fei Guan (2)
Shu-Mei Song (3)
Jian-Kang Jin (3)
Dan-Sheng Lei (4)
Chun-Mei Chen (1)
Jia-Hui Lei (2)
Zheng-Wang Chen (5)
An-Ou Niu (2)
1. Department of Pathology, Hubei Cancer Hospital, Wuhan, China
3. Department of Gastrointestinal Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, USA
2. Department of Parasitology, Tongji Medical College, Huazhong University of Science and Technology, No. 13 Hangkong Road, Wuhan, 430030, China
4. Medicine Laboratory, Hubei Cancer Hospital, Wuhan, China
5. Institute of Biophysics and Biochemistry, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, China - ISSN：1432-1955
文摘
Allograft inflammatory factor-1 (AIF-1) plays an important role in various inflammatory conditions. Our previous study demonstrated that AIF-1 was over-expressed in the liver of BALB/c mice infected with Schistosoma japonicum and played significant role in the pathogenesis of schistosomiasis. The aim of this study was to focus on the effect of AIF-1 treatment on liver fibrosis and necrosis of BALB/c mice infected with S. japonicum. Seventy-two BALB/c mice were infected with cercariae of S. japonicum and then divided into three groups: AIF-1-treated group, saline-treated group, and control group. The vital signs, liver function, egg load, and hepatic pathological changes of the mice were assessed, and the levels of AIF-1 and TNF-α in the liver and spleen were measured at 5, 8, and 14?weeks postinfection. The treatment of AIF-1 on the mice infected with S. japonicum suppressed the expression of TNF-α and increased the effectiveness of AIF-1 in the liver and spleen at 14?weeks postinfection. Histopathological analysis and Masson trichrome staining for the liver tissues showed that the liver fibrosis and necrosis were alleviated previously compared with other infected mice at 14?weeks postinfection. The treatment of AIF-1 on the mice infected with S. japonicum can alleviate hepatic fibrosis and necrosis which indicate that AIF-1 use may prevent and cure the liver fibrosis.