Dendritic amphiphiles of carbosilane dendrimers with peripheral PEG for drug encapsulation

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• 作者：Chunfang Li (1)
  Dongxiang Li (1)
  Chuanlong Qiu (1)
  Wanguo Hou (2)
  
• 关键词：Carbosilane dendrimer ; Fluorescence ; Encapsulation ; Probe molecule
• 刊名：Journal of Polymer Research
• 出版年：2013
• 出版时间：August 2013
• 年：2013
• 卷：20
• 期：8
• 全文大小：263KB
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• 作者单位：Chunfang Li (1)
  Dongxiang Li (1)
  Chuanlong Qiu (1)
  Wanguo Hou (2)
  
  1. Laboratory of Colloid and Functional Nanostructures, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, 266042, China
  2. Key Laboratory of Colloid and Interface Chemistry (Ministry of Education), Shandong University, Jinan, 250100, China
  

文摘

Amphiphilic dendritic macromolecules are suitable for the noncovalent encapsulation of guest molecules and could potentially be applied in drug-delivery systems. In this work, amphiphilic carbosilane dendrimers with peripheral poly(ethylene glycol) (PEG) units were synthesized using a hydrosilylation reaction, and their encapsulation properties were studied by fluorescence spectroscopy, using pyrene as the probe molecule. The results showed that the encapsulating capacity of the dendrimers increased as the number of PEG units increased, and that it also depended to some degree on the dendrimer generation.