A self-powered microfluidic monodispersed droplet generator with capability of multi-sample introduction

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• 作者：Chunyu Li ; Jian Xu ; Bo Ma
• 关键词：Air ; evacuated PDMS ; Droplet generation ; Multi ; sample introduction ; Microfluidics
• 刊名：Microfluidics and Nanofluidics
• 出版年：2015
• 出版时间：May 2015
• 年：2015
• 卷：18
• 期：5-6
• 页码：1067-1073
• 全文大小：1,206 KB
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  Song H
• 作者单位：Chunyu Li (1)
  Jian Xu (1)
  Bo Ma (1)
  
  1. CAS Key Laboratory of Biofuels and Shandong Key Laboratory of Energy Genetics, Single-Cell Center, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, 266101, Shandong, China
  
• 刊物类别：Engineering
• 刊物主题：Engineering Fluid Dynamics
  Medical Microbiology
  Polymer Sciences
  Nanotechnology
  Mechanics, Fluids and Thermodynamics
  Engineering Thermodynamics and Transport Phenomena
  
• 出版者：Springer Berlin / Heidelberg
• ISSN：1613-4990

文摘

We presented a simple, self-powered microfluidic droplet generator capable of generating monodispersed droplets and performing multi-sample introduction. The sealed air-evacuated PDMS channels/chambers provide an internal pumping source, eliminating the needs of external bulky and expensive pumping equipments, and simplifying manual operations. Droplets produced by this droplet generator exhibited a narrow size distribution with a coefficient of variation below 3?%. The droplet size can be controlled in a flexible way by adjusting the hydraulic resistance of the channel networks or the hydrostatic pressure exerted on the inlets. Utilizing this droplet generator, multi-sample introduction was realized by demand-controlled run/stop of the droplet generation or by sequential addition of the different samples during the continuous droplet generation. This self-powered, portable, and easy-to-use droplet generator would extend the droplet-based applications into in-field analysis and facilitate exploitation of droplet microfluidics by non-technical users.