The role of sleep problems and circadian clock genes in attention-deficit hyperactivity disorder and mood disorders during childhood and adolescence: an update
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- 作者：Alexander Dueck ; Christoph Berger ; Katharina Wunsch…
- 关键词：Child and adolescent psychiatry ; ADHD ; MDD ; Animal model ; Circadian rhythm ; Sleep disorder
- 刊名：Journal of Neural Transmission
- 出版年：2017
- 出版时间：February 2017
- 年：2017
- 卷：124
- 期：1-supp
- 页码：127-138
- 全文大小：
- 刊物类别：Medicine
- 刊物主题：Neurology; Psychiatry; Pharmacology/Toxicology; Neurosciences;
- 出版者：Springer Vienna
- ISSN：1435-1463
- 卷排序：124
文摘
A more recent branch of research describes the importance of sleep problems in the development and treatment of mental disorders in children and adolescents, such as attention-deficit hyperactivity disorder (ADHD) and mood disorders (MD). Research about clock genes has continued since 2012 with a focus on metabolic processes within all parts of the mammalian body, but particularly within different cerebral regions. Research has focused on complex regulatory circuits involving clock genes themselves and their influence on circadian rhythms of diverse body functions. Current publications on basic research in human and animal models indicate directions for the treatment of mental disorders targeting circadian rhythms and mechanisms. The most significant lines of research are described in this paper.