Dclk1, a tumor stem cell marker, regulates pro-survival signaling and self-renewal of intestinal tumor cells

详细信息    查看全文

• 作者：Parthasarathy Chandrakesan ; Jiannan Yao ; Dongfeng Qu ; Randal May…
• 关键词：Dclk1 ; APC mutation ; Cancer stem cells ; Intestinal epithelial cells ; Pro ; survival signaling ; Self ; renewal ; Nanoparticles ; Colorectal cancer
• 刊名：Molecular Cancer
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：16
• 期：1
• 全文大小：5689KB
• 刊物主题：Cancer Research; Oncology;
• 出版者：BioMed Central
• ISSN：1476-4598
• 卷排序：16

文摘

BackgroundMore than 80% of intestinal neoplasia is associated with the adenomatous polyposis coli (APC) mutation. Doublecortin-like kinase 1 (Dclk1), a kinase protein, is overexpressed in colorectal cancer and specifically marks tumor stem cells (TSCs) that self-renew and increased the tumor progeny in ApcMin/+ mice. However, the role of Dclk1 expression and its contribution to regulating pro-survival signaling for tumor progression in Apc mutant cancer is poorly understood.