Assessing behavioural and cognitive domains of autism spectrum disorders in rodents: current status and future perspectives
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- 作者：Martien J. Kas (1)
Jeffrey C. Glennon (2)
Jan Buitelaar (2)
Elodie Ey (3) (4) (5)
Barbara Biemans (6)
Jacqueline Crawley (7)
Robert H. Ring (8)
Clara Lajonchere (8) (9)
Frederic Esclassan (10)
John Talpos (11)
Lucas P. J. J. Noldus (12)
J. Peter H. Burbach (1)
Thomas Steckler (11) - 关键词：Behaviour ; Cognition ; Animal model ; Genetics ; Phenotype
- 刊名：Psychopharmacology
- 出版年：2014
- 出版时间：March 2014
- 年：2014
- 卷：231
- 期：6
- 页码：1125-1146
- 全文大小：584 KB
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Jeffrey C. Glennon (2)
Jan Buitelaar (2)
Elodie Ey (3) (4) (5)
Barbara Biemans (6)
Jacqueline Crawley (7)
Robert H. Ring (8)
Clara Lajonchere (8) (9)
Frederic Esclassan (10)
John Talpos (11)
Lucas P. J. J. Noldus (12)
J. Peter H. Burbach (1)
Thomas Steckler (11)
1. Department of Translational Neuroscience, Brain Center Rudolf Magnus, University Medical Center Utrecht, Utrecht, The Netherlands
2. Donders Institute for Brain, Cognition and Behaviour, Department of Cognitive Neuroscience, and Karakter Child and Adolescent Psychiatry University Center, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
3. Human Genetics and Cognitive Functions, Institute Pasteur, Paris, France
4. CNRS URA 2182 鈥楪enes, Synapses and Cognition鈥? Institut Pasteur, Paris, France
5. Sorbonne Paris Cit茅, Human Genetics and Cognitive Functions, University Paris Diderot, Paris, France
6. Department of Neuroscience, F. Hoffmann-La Roche Ltd., Grenzacherstrasse 124, 4070, Basel, Switzerland
7. Department of Psychiatry and Behavioral Sciences, University of California Davis School of Medicine Sacramento, Sacramento, USA
8. Autism speaks, Princeton, NJ, USA
9. Department of Biomedical Engineering, Keck School of Medicine University of Southern California, California, USA
10. Lilly Centre for Cognitive Neuroscience, Lilly Research Laboratories, Eli Lilly & Co. Ltd, Erl Wood Manor, Sunninghill Road, Windlesham, Surrey, GU20 6PH, England, UK
11. Janssen Research & Development, Turnhoutseweg 30, 2340, Beerse, Belgium
12. Noldus Information Technology BV, Wageningen, The Netherlands - ISSN：1432-2072
文摘
The establishment of robust and replicable behavioural testing paradigms with translational value for psychiatric diseases is a major step forward in developing and testing etiology-directed treatment for these complex disorders. Based on the existing literature, we have generated an inventory of applied rodent behavioural testing paradigms relevant to autism spectrum disorders (ASD). This inventory focused on previously used paradigms that assess behavioural domains that are affected in ASD, such as social interaction, social communication, repetitive behaviours and behavioural inflexibility, cognition as well as anxiety behaviour. A wide range of behavioural testing paradigms for rodents were identified. However, the level of face and construct validity is highly variable. The predictive validity of these paradigms is unknown, as etiology-directed treatments for ASD are currently not on the market. To optimise these studies, future efforts should address aspects of reproducibility and take into account data about the neurodevelopmental underpinnings and trajectory of ASD. In addition, with the increasing knowledge of processes underlying ASD, such as sensory information processes and synaptic plasticity, phenotyping efforts should include multi-level automated analysis of, for example, representative task-related behavioural and electrophysiological read-outs.