Epigenetic treatment of solid tumours: a review of clinical trials
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- 作者：Clara Nervi ; Elisabetta De Marinis ; Giovanni Codacci-Pisanelli
- 关键词：Epigenetic treatment ; Histone deacetylases (HDACs) ; Histone methyltransferases (HMTs) ; DNA methylation ; DNA ; methyltransferases ; ncRNAs ; Azacytidine ; Decitabine ; Valproic acid ; Suberoylanilide hydroxamic acid (SAHA)
- 刊名：Clinical Epigenetics
- 出版年：2015
- 出版时间：December 2015
- 年：2015
- 卷：7
- 期：1
- 全文大小：969 KB
- 刊物主题：Human Genetics; Gene Function;
- 出版者：BioMed Central
- ISSN：1868-7083
文摘
Epigenetic treatment has been approved by regulatory agencies for haematological malignancies. The success observed in cutaneous lymphomas represents a proof of principle that similar results may be obtained in solid tumours. Several agents that interfere with DNA methylation-demethylation and histones acetylation/deacetylation have been studied, and some (such as azacytidine, decitabine, valproic acid and vorinostat) are already in clinical use.