Claudin-17 reduced expression is associated with high histologic grade and shorter overall survival in canine mammary carcinoma
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- 作者：Massoud Rezaee ; Ahmad Reza Movassaghi ; Mohsen Maleki
- 关键词：Canine mammary carcinomas ; Claudin ; 17 ; Tight junction ; Immunohistochemistry.
- 刊名：Comparative Clinical Pathology
- 出版年：2017
- 出版时间：January 2017
- 年：2017
- 卷：26
- 期：1
- 页码：143-146
- 全文大小：
- 刊物类别：Medicine
- 刊物主题：Pathology; Hematology; Oncology;
- 出版者：Springer London
- ISSN：1618-565X
- 卷排序：26
文摘
The present study investigates Claudin-17 expression in canine mammary carcinomas by means of immunohistochemistry and its relationships with histologic grades, overall survival and tumour recurrence. Our results show that Claudin-17 expression is reduced significantly in canine mammary carcinomas compared with normal canine mammary tissues. High histologic grade and shorter overall survival have been shown to be significantly associated with Claudin-17 reduced expression. Results of this study suggest a possible relationship between reduction of Claudin-17 and canine mammary carcinoma pathogenesis.