Translational models for vascular cognitive impairment: a review including larger species

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• 作者：Atticus H. Hainsworth ; Stuart M. Allan ; Johannes Boltze…
• 关键词：Vascular dementia ; Vascular cognitive impairment ; VCID ; Experimental models ; In vivo models ; Translational models
• 刊名：BMC Medicine
• 出版年：2017
• 出版时间：December 2017
• 年：2017
• 卷：15
• 期：1
• 全文大小：2321KB
• 刊物主题：Medicine/Public Health, general; Biomedicine, general;
• 出版者：BioMed Central
• ISSN：1741-7015
• 卷排序：15

文摘

BackgroundDisease models are useful for prospective studies of pathology, identification of molecular and cellular mechanisms, pre-clinical testing of interventions, and validation of clinical biomarkers. Here, we review animal models relevant to vascular cognitive impairment (VCI). A synopsis of each model was initially presented by expert practitioners. Synopses were refined by the authors, and subsequently by the scientific committee of a recent conference (International Conference on Vascular Dementia 2015). Only peer-reviewed sources were cited.